Alzheimer&Dementia: Control blood sugar, stabilize glycation, diabetes can double the risk of dementia!

Type 2 diabetes (T2D) and dementia are the two biggest public health challenges in our aging society
.

There are 463 million adults worldwide with diabetes and 374 million people with prediabetes

Diabetic cognitive impairment (usually the prodromal stage of dementia) affects 20% of people 65 years of age or older, and about one-third of these cases will develop dementia within 5 years

In addition, although there is evidence that pre-diabetes is related to changes in cognitive function and brain integrity , few studies have involved the relationship between pre-diabetes and cognitive impairment, and the results are conflicting
.

In addition, with the exception of diabetes, the effect of blood glucose control levels on the preclinical/prodromal stages of dementia (ie, cognitive impairment) has hardly been studied

There is evidence that pre-diabetes is related to changes in cognitive function and brain integrity.

In order to fully explore the impact of diabetes on the prodromal stage of dementia, experts from the neurobiology of the Karolinska Institute in Stockholm, Sweden have carried out relevant research on cognitive health (n = 1840) or cognitive impairment-no dementia (CIND).
; N = 682) of the elderly cohort conducted a 12-year follow-up survey to detect the occurrence of CIND and dementia respectively
.

The results were published in the journal Alzheimer & Dementia

The results showed that poor diabetes control (glycated hemoglobin [HbA1c] ≥ 7.
5%; reference value = euglycemia) doubled the risk of CIND (Cox regression multi-adjusted hazard ratio [HR] = 2.
01, 95% confidence interval [CI] 1.
13-3.
58 ) Is related to 3 times the risk of CIND progression to dementia (HR = 2.
87, 95% CI 1.
20-6.
85)
.

Combining diabetes and heart disease doubles the risk of CIND and dementia, although neither disease alone brings any significant risk of outcome

Poor diabetes control (glycated hemoglobin [HbA1c] ≥ 7.

The combined effect of diabetes and heart disease (HD) on cognitive impairment-no dementia (CIND) and its development to dementia

At the same time, compared with people with normal blood sugar and elevated CRP levels, people with diabetes and elevated CRP have a three-fold risk of CIND progression to dementia (HR=3.
3, 95% CI 1.
02-10.
91))
.

In addition, diabetes and elevated CRP levels had a marginally significant multiplicative interaction on the progression of CIND to dementia (P=0.

At the same time, compared with people with normal blood sugar and elevated CRP levels, people with diabetes and elevated CRP have a three-fold risk of CIND progression to dementia (HR=3.

In summary, to poor glycemic control or heart vascular complications characterized by risk and the development of diabetes and greater cognitive impairment related to inflammation may play a role in these relations

references:

The impact of diabetes on cognitive impairment and its progression to dementia.

The impact of diabetes on cognitive impairment and its progression to dementia.
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