Alzheimer Dementia: Long-term poor sleep makes it easy to become "silly"

At present, the median age of the world's population is rising rapidly
.

In the United States, the proportion of people aged 65 or older is expected to increase from 12.

The poor sleep quality of the elderly is related to the decline of neurocognitive ability and the occurrence of dementia
.

The literature on the elderly with chronic insomnia further shows that the incidence of cognitive impairment is high, especially in the measurement of executive function

Common factors associated with SDB and insufficient sleep in the elderly include metabolic syndrome (MetS) and some of its components (ie obesity, hypertension, and diabetes )
.

Compared with non-Hispanic whites, Hispanics/Latinos have a significantly higher risk of MetS, and the risk of Alzheimer's disease and related dementia (ADRD) is four times higher

Metabolic syndrome diabetes

Longitudinal studies have also shown that symptoms of insomnia and SDB can predict MetS events after 3 years
.

In different cohorts of Hispanic/Latino adults, there was a strong association between short SD and daytime naps and obesity

Among Hispanic/Latino adults older than 65, MetS and obesity have a higher incidence
.

At present, there are few studies directly studying the metabolic pathways of sleep measures predicting neurocognitive decline in different age and gender groups, especially among vulnerable Hispanic/Latino participants

In this way, Sonya S.
Kaur and others of the University of Miami studied the influence of MetS and obesity on the relationship between sleep phenotype and neurocognitive dysfunction and decline of Hispanic/Latino adults of different ages and gender groups.

.

The effects of MetS and obesity on the relationship between sleep phenotype and neurocognitive dysfunction and decline of Hispanic/Latino adults of different ages and gender groups were studied
.

The effects of MetS and obesity on the relationship between sleep phenotype and neurocognitive dysfunction and decline of Hispanic/Latino adults of different ages and gender groups were studied

They found that the average age was 56.
0 years and 54.
8% were women
.

Obesity changed the association between SDB/SD and ND in the oldest age group in terms of memory (F = 21.

Women without MetS showed the most significant overall cognitive decline when combined with long sleep/SDB (F = 3.
07, P = 0.
010)
.

The significance of this study is to: found in obese elderly, merge SDB / long sleep and memory, the overall recognition known relationship between the most significant decline
.

In women, MetS status changes the link between long sleep/SDB and overall cognitive decline

We found in obese elderly, merge SDB / long sleep and memory, as a whole recognize the relationship between the knowledge of the most significant decline
.
In women, MetS status changes the link between long sleep/SDB and overall cognitive decline
.
We found in obese elderly, merge SDB / long sleep and memory, as a whole recognize the relationship between the knowledge of the most significant decline
.
In women, MetS status changes the link between long sleep/SDB and overall cognitive decline
.
Overall recognition

Original Source:
Kaur SS, Tarraf W, Wu B, Gonzalez KA, Daviglus M, Shah N, Sotres-Alvarez D, Gallo LC, Wohlgemuth W, Redline S, Gonzalez HM, Ramos AR.
Modifying pathways by age and sex for the association between combined sleep disordered breathing and long sleep duration with neurocognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Alzheimers Dement.
2021 May 25.
doi: 10.
1002/alz.
12361.
Epub ahead of print.
PMID: 34032354.

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