echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Alzheimer's cognitive decline "culprit" revealed

    Alzheimer's cognitive decline "culprit" revealed

    • Last Update: 2022-03-03
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    According to a study published in the journal Alzheimer's Disease and Dementia on the 17th, advanced imaging technology developed by Yale University researchers helped them confirm that the destruction of brain synapses is a key factor in cognitive impairment in Alzheimer's patients.


    Scientists have believed for years that the loss of connections between brain cells leads to Alzheimer's-related symptoms, including memory loss, but the actual evidence for the effects of the loss of brain synapses has been limited to the middle and late stages.


    PET imaging scans of the new glycoprotein 2A (SV2A) allowed scientists to measure the metabolic activity of brain synapses in 45 people diagnosed with mild to moderate Alzheimer's disease


    They found that loss of synapses, or connections, between brain cells was strongly associated with poor performance on cognitive tests


    Researchers can now track patients' loss of synapses over time to better understand individual cognitive decline, said Christopher Van Dyke, director of the Yale Alzheimer's Disease Research Center and senior author of the paper.


    "These findings help us understand the neurobiology of the disease and could be important new biomarkers for testing the efficacy of new Alzheimer's drugs," said lead author Don McCain


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.