echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > Alzheimers Dement: Middle-aged people with good cardiovascular conditions have a lower risk of dementia

    Alzheimers Dement: Middle-aged people with good cardiovascular conditions have a lower risk of dementia

    • Last Update: 2022-11-04
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Dementia is a devastating disease and it is crucial
    to prevent cognitive decline early before symptoms of dementia appear.
    Given the multifactorial nature of dementia, interventions targeting multiple risk factors may be required simultaneously throughout life for optimal prevention
    .
    Vascular risk factors are increasingly recognized as important factors in the development of dementia and, therefore, potential targets for
    early preventive therapy.

    Sanaz Sedaghat et al.
    published a research paper
    in Alzheimers Dement evaluating whether improvements in cardiovascular health in midlife and improvements in cardiovascular health in midlife were associated
    with dementia risk.

    Through a series of examinations of two population-based cohorts from different time periods, the Community Atherosclerosis Risk (ARIC) Study and the Age, Gene/Environmental Sensitivity (AGES)-Reykjavik Study, which sought to assess higher levels in middle age Whether improvements in CVH and CVH in middle age were associated
    with a lower risk of dementia.
    In secondary analyses, attempts were made to assess whether higher
    CVH in old age and improvement in CVH from middle to old age were associated
    with a lower risk of dementia.

    Two population-based longitudinal studies were used: community atherosclerosis risk (ARIC) (n = 11,460 times at 54 and 60 years).
    and age, genetic/environmental sensitivity (ages) - Reykjavik (n = 3907/time, 51 years).

    。 A
    cardiovascular health score (range 0-12/0-14) was calculated at each visit, including 6/7 items, with each item weighted as poor (0), moderate (1) or ideal (2).

    Cardiovascular health is defined as low
    (0-4/0-5), moderate (5-7/6-9), or high (8-12/10-14).

    Incidental dementia was identified through links to health records and neuropsychological
    examinations.

    1.
    Better cardiovascular health in midlife was associated with a lower risk of dementia (hazard ratio [HR]: ARIC: 0.
    60 [95% confidence interval, CI: 0.
    52, 0.
    69]); For AGES - Reykjavik: 0.
    83 [0.
    66, 0.
    99].

    Heatmap
    of participants and dementia cases in the middle-aged cardiovascular health status category at community atherosclerosis risk (n = 11,460).

    2.
    Improved cardiovascular health in midlife was associated with a reduced risk of dementia (for each additional point in HR: ARIC: 0.
    94 [0.
    92, 0.
    96]).

    Promoting cardiovascular health in midlife can help reduce the risk of
    dementia.

    Higher CVH and improved CVH in middle age were associated
    with a lower risk of dementia.
    These findings could have important public health implications, underscoring the need to raise and maintain an ideal
    CVH in middle age to
    reduce dementia risk.

    Original source:

    Sedaghat S, Lutsey PL, Ji Y, et al.
    Association of change in cardiovascular risk factors with incident dementia [published online ahead of print, 2022 Oct 27].
    Alzheimers Dement.
    2022; 10.
    1002/alz.
    12818.
    doi:10.
    1002/alz.
    12818

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.