Alzheimer's Dementia |。 Increased vitamin D intake can reduce the risk of dementia

Vitamin D deficiency is common among the general population and the elderly, but is not fully recognized.
and vitamin D deficiency is a potentially changeable risk factor for dementia.
low vitamin D levels may be a risk factor for cognitive impairment and can lead to subsequent dementia through a variety of potential mechanisms.
vitamin D is distributed throughout the brain, and evidence from immunobiochemical chemistry suggests that it is confined to the nuclei of the cells, suggesting a "neurosteroid" side secretion/vitamin D self-secretion function.
Vitamin D plays a wide range of protective roles on the central nervous system by regulating neurotrophic factors, inducing the removal of β amyloid proteins (a beta), maintaining calcium stability, regulating oxidative stress, and regulating immune response.
epidemiological studies have consistently found a link between low levels of circulating vitamin D and an increased risk of dementia.
there is some evidence that taking more vitamin D can reduce the risk of dementia or raise awareness.
previous studies were mostly based on whites, which may limit the expansion of their conclusions.
a recent multiracial group study found that people with lower serum vitamin D levels had faster cognitive decline.
, however, the study did not have data on dietary intake.
, based on Washington Heights-Inwood Columbia Aging Project (WHICAP), tried to address the limitations of previous studies.
found that 329 participants developed dementia over an average of 5.8 years of follow-up.
Compared to the lowest 1/3 participants with the lowest vitamin D intake in food, the 1/3 participants with the highest intake (highest tertile), the risk of dementia was reduced (HR=0.72), age, gender, race/ethnicity, education, type E lipid protein (APOE)-4, physical activity, Mediterranean diet scores, income, depression, hypertension, diabetes, cardiovascular disease and smoking.
the study concluded that increased vitamin D intake was associated with a reduced risk of dementia in multiracial groups.
, more sun exposure or appropriate vitamin D supplementation can be appropriate to prevent dementia.
Zhao, C., Tsapanou, A., Manly, J., Schupf, N., Brickman, A.M., samp; Gu, Y. (2020). Vitamin D intake is associated with dementia risk in the Washington Heights‐Inwood Columbia Aging Project (WHICAP). Alzheimer's & Dementia, 16(10), 1393-1401.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjMwMjMtMTYwOTAxMzUwNzEwMyIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiLnu7QiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueUnyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi57SgIiwic3R5bGVzIjp7ImZvbnQtc2l6Z。 SI6MTZ9fSx7ImNoYXIiOiJEIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnvLoiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuS5jyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55eHIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlnKgiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuaZriIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi6YCaIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkuroiLCJzdHlsZX。 MiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6Iue+。 pCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5ZKMIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLogIEiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuW5tCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5Lq6Iiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkuK0iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IumdniIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5bi4Iiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6M。 TZ9fSx7ImNoYXIiOiLmma4iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IumBjSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi77yMIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLpgJoiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuW4uCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5pyqIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLooqsiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuWFhSIsInN0eWxlcy。 I6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5YiGIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLorqQiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuivhiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi55qEIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLjgIIiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuiAjCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5LiUIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXI。 iOiLnu7QiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueUnyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi57SgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiJEIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnvLoiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuS5jyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5pivIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLkuIAiLCJzdHlsZXMiOnsiZm9udC1zaXpl。 IjoxNn19LHsiY2hhciI6IuS4qiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5r2cIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlnKgiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueahCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi44CBIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLlj68iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IuaUuSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5Y。 +YIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnmoQiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueXtCIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5ZGGIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLpo44iLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IumZqSIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5ZugIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLntKAiLCJzdHlsZXMiOnsiZm9udC1zaXplIjo。 xNn19LHsiY2hhciI6IuOAgiIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi5L2OIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLnu7QiLCJzdHlsZXMiOnsiZm9udC1zaXplIjoxNn19LHsiY2hhciI6IueUnyIsInN0eWxlcyI6eyJmb250LXNpemUiOjE2fX0seyJjaGFyIjoi57SgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiJEIiwic3R5bGVzIjp7ImZvbnQtc2l6ZSI6MTZ9fSx7ImNoYXIiOiLmsLQiLCJz。