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Due to the aging of the world's population, dementia will increasingly become a challenge facing individuals and society.
prevention
Some longitudinal studies have found that certain diseases (such as diabetes , atrial fibrillation, depression) are risk conditions that lead to an increased incidence of dementia.
Diabetes up to 90% of adults over the age of 60 have two or more chronic diseases, this condition is called frequently-occurring disease.
Due to similar pathophysiological mechanisms and/or common risk factors, some diseases tend to cluster in the same person, which leads to a multi-pathological pattern characterized by chronic diseases that cluster together systematically.
Inflammation is one of the factors related to specific frequently-occurring patterns and dementia.
Inflammation is one of the factors related to specific frequently-occurring patterns and dementia.
Based on the above hypothesis, experts from the Karolinska Institute in Sweden and the Center for Aging Research in the Department of Neurobiology and Sociology at Stockholm University investigated the risk of dementia in the elderly with different disease patterns and explored inflammation and lipoprotein E (APOE) The role of genotype.
The researchers included 2478 participants without dementia in the Swedish National Aging and Nursing Study (SNAC-K), who had two or more chronic diseases (ie frequently-occurring diseases), and were grouped according to their frequently-occurring patterns.
Divided by the baseline frequent incidence pattern, the incidence of dementia per 100 person-years and the adjusted risk ratio
Divided by the baseline frequent incidence pattern, the incidence of dementia per 100 person-years and the adjusted risk ratioThe results showed that compared with participants suffering from non-specific disease, suffering from neuropsychiatric, medsci.
Suffering from neuropsychiatric, medsci.
High CRP increases the risk of dementia, and being a carrier of APOE ε4 increases the risk of neuropsychiatric and cardiovascular dementia.
According to the serum CRP level and APOE genotype, according to the baseline frequent incidence pattern, the incidence of dementia per 100 person-years and the adjusted risk ratio
According to the serum CRP level and APOE genotype, according to the baseline frequent incidence pattern, the incidence of dementia per 100 person-years and the adjusted risk ratioIt can be seen that people with neuropsychiatric, cardiovascular, and sensory disorders/cancer patterns have an increased risk of dementia and APOE ε4, and inflammation may further increase the risk.
It can be seen that people with neuropsychiatric, cardiovascular, and sensory disorders/cancer patterns have an increased risk of dementia and APOE ε4, and inflammation may further increase the risk.
references:
onlinelibrary.
onlinelibrary.
wiley.
com/doi/epdf/10.
1002/alz.
12237" target="_blank" rel="noopener">Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics.
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