Alzheimers Dementia: Lower systolic blood pressure lowers dementia risk later in life

Elevated systolic blood pressure (SBP), especially in middle age, increases the risk of dementia

The point of contention is:

• Increased blood pressure contributes to the amount of amyloid beta (Aβ) deposited in the brain;
• Higher blood pressure is a risk factor for cerebrovascular disease, which then leads to Aβ and phosphorylated tau (pTau) deposition and neurodegeneration and dementia
  
  

  Participants with or without antihypertensive medication (AHM) confounded many studies on hypertension, cerebrovascular disease, and dementia risk

  
  

  Trials of antihypertensive drugs had little effect on reducing the incidence of dementia

  
  

  The University of Pittsburgh's Lewis H.

  
  

  In GEMS, they assessed the association of SBP measured between 2000 and 2006 with dementia risk and brain biomarkers in 2009-2020 (n = 177), with a mean age of 95 years in 2020

  
  

  They found that by 2020, only 9 (5%) of 177 patients were alive and cognitively impaired (CU)

  
  

  The amount of Aβ is directly related to the level of SBP

  
  

  Apart from Aβ, SBP emerged as an important predictor of dementia

  
  

  The significance of the study was its finding that low SBP without antihypertensive medication was associated with a significantly lower risk of dementia and less Aβ

  
  Low SBP without antihypertensive medication was associated with a significantly lower risk of dementia and less Aβ
  
  
  
  ow untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+.
  Alzheimer's & Dementia.
  
  
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