Alzheimers Dementia: Pathological protein levels in cerebrospinal fluid, which can reflect the density of cortical neurons

Recent advances in multi-shell DWI (multi-shell) acquisition and multi-chamber modeling technology have greatly improved the ability to study the microstructure of the cortex.

These subcomponents are used to calculate two quantitative microstructure indicators.

An important aspect of NODDI is the modeling of free water (including cerebrospinal fluid [CSF]), which helps explain partial volume effects, making it particularly suitable for studying cortical microstructure, especially in neurodegeneration Disease.

Previous studies used the NODDI model to investigate the changes in the microstructure of the cortex in clinical AD, indicating that in young-onset and sporadic AD participants, NDI and ODI in a wide range of cortical areas are both low.

However, whether the microstructure of cortical NDI is related to the pathology of AD before the onset of cognitive impairment remains to be determined.

They found that Aβ42/Aβ40 × p-tau had a significant interaction effect on the cortical neuron density index (NDI), but had no effect on the orientation dispersion index or cortical thickness.

The important significance of this study is that it is found that NDI is a particularly sensitive marker of early cortical changes that occur before severe atrophy or the development of cognitive impairment.