Alzheimer's Dementia |。 People who don't sleep well are more likely to have dementia

Sleep is essential to the brain because it facilitates learning and memory, regulates synaptic plasticity, and enhances brain waste removal.
, sleep disturbances can damage the brain by increasing nerve inflammation or atherosclerosis, or by accumulating harmful proteins associated with Alzheimer's disease (AD) pathology.
have found that sleep disorders are related to the onset of dementia and are therefore considered a potential risk factor for dementia.
sleep is closely related to the circadian rhythm system, and this function of circadian rhythm can be reflected in the rhythm of physical activity within 24 hours.
24-hour activity rhythm disorder is also associated with a risk of dementia.
, however, as far as the risk of dementia is concerned, it is still unclear what similarities and differences the rhythms of sleep and 24-hour activity have on it, and whether their images of dementia risk are independent.
, however, only a few population-based studies objectively measured the relationship between sleep and dementia risk.
They measure sleep primarily using self-reporting methods, which are feasible in a large number of study populations, but these self-reported subjective evaluations are influenced by cognitive and emotional factors, which can prevent a complete and regular assessment of sleep.
Thom S. Lysen of the University of Rotterdam in the Netherlands and others followed 1,322 non-dementia patients for 11.2 years, using actigraphy to objectively assess sleep and 24-hour activity rhythms and explore their relationship to Alzheimer's risk.
: During the 11-year follow-up period, 60 patients were diagnosed with dementia, 49 of whom had Alzheimer's disease (AD).
longer sleep incubation periods (lying down to fall asleep), longer wake-up times after sleep begins, longer bedtimes, and lower sleep efficiency increase the risk of dementia, especially AD-type dementia.
but the 24-hour activity rhythm was independent of the risk of dementia.
the study is that poor sleep, rather than a 24-hour rhythm disorder, is associated with an increased risk of dementia.
use of motion pictures to help objectively assess sleep and reduce the risk of dementia in terms of improving sleep quality.
Lysen, T. S., Luik, A. I., Ikram, M. K., Tiemeier, H., & Ikram, M. A. (2020). Actigraphy‐estimated sleep and 24‐hour activity rhythms and the risk of dementia. Alzheimer's & Dementia, 16(9), 1259-1267.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjE3MDAtMTYwOTEwMTUxNzAzOSIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOltdLCJpc1JpY2hUZXh0Ijp0cnVlLCJrZWVwTGluZUJyZWFrIjp0cnVlfX0seyJibG9ja0lkIjoiMjA0OS0xNjA5MTAzNjA0ODI2IiwiYmxvY2tUeXBlIjoicGFyYWdyYXBoIiwic3R5bGVzIjp7ImFsaWduI。 joibGVmdCIsImluZGVudCI6MCwidGV4dC1pbmRlbnQiOjAsImxpbmUtaGVpZ2h0IjoxLjc1LCJiYWNrLWNvbG9yIjoiIiwicGFkZGluZyI6IiJ9LCJ0eXBlIjoicGFyYWdyYXBoIiwicmljaFRleHQiOnsiZGF0YSI6W3siY2hhciI6IkEiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoibCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJ6Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImgiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0sey。 JjaGFyIjoiZSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJpIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Im0iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiZSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJyIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuKAmSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJzIiwic3R5bGVzIjp7ImJhY2stY29。 sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IiAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiRCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJlIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Im0iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiZSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJuIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6InQiLCJz。 dHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiaSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJhIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IiAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiLSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuedoSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZ。 iJ9fSx7ImNoYXIiOiLnnKAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5LiNIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuWlvSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnmoQiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5Lq6Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6Iu。 +8jCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLmm7QiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5a65Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuaYkyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnl7QiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5ZGGIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19XSwiaXNSaWNoVGV4dCI6dHJ1ZSwia2VlcExpbmV。 CcmVhayI6dHJ1ZX19LHsiYmxvY2tJZCI6IjM2MjItMTYwOTEwMzYwNjA2OCIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiIiwiYWxpZ24iOiJsZWZ0IiwiaW5kZW50IjowLCJ0ZXh0LWluZGVudCI6MCwibGluZS1oZWlnaHQiOjEuNzUsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiLCoCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fV0sImlzUmljaFRleHQiOnRydWUsImtlZXBMaW5lQnJlYWsiOnRydWV9fSx7ImJsb2NrSWQiOiI5。 NDM0LTE2MDkxMDM2MDYwNjkiLCJibG9ja1R5cGUiOiJwYXJhZ3JhcGgiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiIsImFsaWduIjoibGVmdCIsImluZGVudCI6MCwidGV4dC1pbmRlbnQiOjAsImxpbmUtaGVpZ2h0IjoxLjc1LCJwYWRkaW5nIjoiIn0sInR5cGUiOiJwYXJhZ3JhcGgiLCJyaWNoVGV4dCI6eyJkYXRhIjpbeyJjaGFyIjoiwqAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX1dLCJpc1JpY2hUZXh0Ijp0cnVlLCJrZWVwTGluZUJyZWFrIjp0cnVlfX0seyJibG9ja0lkIjoiMTc4Ni0xNjA5MTAzNjA1MDc0IiwiYmxvY2tUe。 XBlIjoicGFyYWdyYXBoIiwic3R5bGVzIjp7ImFsaWduIjoibGVmdCIsImluZGVudCI6MCwidGV4dC1pbmRlbnQiOjAsImxpbmUtaGVpZ2h0IjoxLjc1LCJiYWNrLWNvbG9yIjoiIiwicGFkZGluZyI6IiJ9LCJ0eXBlIjoicGFyYWdyYXBoIiwicmljaFRl。