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Alzheimer's & Dementia: Physical activity in older adults is associated with markers of synaptic integrity in brain tissue

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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Physical activity (PA) is widely recommended for studies of age-related brain health, but its neurobiology is not well understood
.

Animal models suggest that PA is synaptic

In the journal Alzheimer's & Dementia, Kaitlin Casaletto et al.
investigated the relationship between PA and markers of synaptic integrity in the elderly
.

Subjects from the Rush Memory and Aging Project completed annual activity monitoring (mean number of visits = 3.
5 ± 2.
4) and postmortem assessments
.

Brain tissue presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, synthetic proteins, complex I and complex II) and neuropathology were analyzed

Increased mean physical activity in later life .

Increased mean annual physical activity was associated with higher levels of synaptic proteins in brain tissue at death, with the exception of complex-II
.

The closer the measures were taken in time (i.

Greater PA in later life was associated with higher presynaptic protein levels (0.

This study is the first to demonstrate a link between life>

original source

Late-life physical activity relates to brain tissue synaptic integrity markers in older adults

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