Alzheimer's Dementia |。 Shanghai Aging Research: Serum metabolite markers can predict dementia in advance

Dementia has become a major public health challenge and has created a considerable financial burden.
, however, there is currently no effective prevention and treatment of late-onset dementia.
the amyloid cascading reaction hypothesis and vascular dysfunction have been the two main disease-caused concepts in dementia research.
, however, anti-amyloid antibody therapy does not improve cognitive function in Alzheimer's (AD) patients, and the control of vascular factors does little to reduce the progression of dementia.
it is therefore necessary to understand other pathophysiological pathogenic pathogenesies of dementia in order to develop therapeutic targets and to detect biomarkers that help identify high-risk populations at an early stage in order to initiate prevention, monitoring and treatment.
The use of blood metabolomic methods to detect circulating metabolites to reflect the interaction of genetic and environmental factors, as well as metabolic changes in the brain or cerebral fluid, is promising for exploring the pathophysiology of dementia and identifying biomarkers of dementia.
recent studies have shown that altered serum metabolites are associated with the onset of dementia, however, these studies have been conducted in developed countries with inconsistent results.
, of Fudan University, analyzed 38 metabolites in the serum of 1,440 dementia-free patients followed by the Shanghai Aging Study using nuclear magnetic resonance technology (NMR).
results showed that elevated levels of serum glutamine and O-acetylamide were associated with an increased risk of dementia, while glutamate, tyrosine, acetic acid, glycine and phenylalanine were negatively associated with dementia.
addition, dementia can be predicted by a combination of five metabolites screened using the LASSO (least absolute shrinkage and selection operator) method.
importance of this clinical research queue is that, based on the Chinese group, they identified seven serum metabolite markers that indirectly predict dementia.
, these findings and potential biological mechanisms need to be further repeated and clarified in future studies.
Cui, M., Jiang, Y., Zhao, Q., Zhu, Z., Liang, X., Zhang, K., ... & Ding, D. (2020). Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study. Alzheimer's & Dementia , 16 (5), 779-788.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjI3NTgtMTYwOTI4MDQ3MzQ1NCIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOltdLCJpc1JpY2hUZXh0Ijp0cnVlLCJrZWVwTGluZUJyZWFrIjp0cnVlfX0seyJibG9ja0lkIjoiNjU3Mi0xNjA5MjgxMDU0Njk5IiwiYmxvY2tUeXBlIjoicGFyYWdyYXBoIiwic3R5bGVzIjp7ImFsaWduI。 joibGVmdCIsImluZGVudCI6MCwidGV4dC1pbmRlbnQiOjAsImxpbmUtaGVpZ2h0IjoxLjc1LCJiYWNrLWNvbG9yIjoiIiwicGFkZGluZyI6IiJ9LCJ0eXBlIjoicGFyYWdyYXBoIiwicmljaFRleHQiOnsiZGF0YSI6W3siY2hhciI6IueXtCJ9LHsiY2hhciI6IuWRhiJ9LHsiY2hhciI6IueXhyJ9LHsiY2hhciI6IuW3siJ9LHsiY2hhciI6IuaIkCJ9LHsiY2hhciI6IuS4uiJ9LHsiY2hhciI6IuS4gCJ9LHsiY2hhciI6IuS4qiJ9LHsiY2hhciI6IumHjSJ9LHsiY2hhciI6IuWkpyJ9LHsiY2hhciI6IueahCJ9LHsiY2hhciI6IuWFrCJ9LHsiY2hhciI6Iu。 WFsSJ9LHsiY2hhciI6IuWNqyJ9LHsiY2hhciI6IueUnyJ9LHsiY2hhciI6IuaMkSJ9LHsiY2hhciI6IuaImCJ9LHsiY2hhciI6Iu+。 8jCJ9LHsiY2hhciI6IuW5tiJ9LHsiY2hhciI6IumAoCJ9LHsiY2hhciI6IuaIkCJ9LHsiY2hhciI6IuS6hiJ9LHsiY2hhciI6IuebuCJ9LHsiY2hhciI6IuW9kyJ9LHsiY2hhciI6IuWkpyJ9LHsiY2hhciI6IueahCJ9LHsiY2hhciI6Iue7jyJ9LHsiY2hhciI6Iua1jiJ9LHsiY2hhciI6Iui0nyJ9LHsiY2hhciI6IuaLhSJ9LHsiY2hhciI6IuOAgiJ9LHsiY2hhciI6IueEtiJ9LHsiY2hhciI6IuiAjCJ9LHsiY2hhciI6Iu+。 8jCJ9LHsiY2hhciI6IuebriJ9LHsiY2hhciI6IuWJjSJ9LHsiY2hhciI6Iui/mCJ9LHsiY2hhciI6IuayoSJ9LHsiY2hhciI6IuaciSJ9LHsiY2hhciI6IuaciSJ9LHsiY2hhciI6IuaViCJ9LHsiY2hhciI6IueahCJ9LHsiY2hhciI6IumihCJ9LHsiY2hhciI6IumYsiJ9LHsiY2hhciI6IuWSjCJ9LHsiY2hhciI6IuayuyJ9LHsiY2hhciI6IueWlyJ9LHsiY2hhciI6Iui/ nyJ9LHsiY2hhciI6IuWPkSJ9LHsiY2hhciI6IuaApyJ9LHsiY2hhciI6IueXtCJ9LHsiY2hhciI6IuWRhiJ9LHsiY2hhciI6IueXhyJ9LHsiY2hhciI6Iu+。 8iCJ9LHsiY2hhciI6ImwifSx7ImNoYXIiOiJhIn0seyJjaGFyIjoidCJ9LHsiY2hhciI6ImUifSx7ImNoYXIiOiItIn0seyJjaGFyIjoibyJ9LHsiY2hhciI6Im4ifSx7ImNoYXIiOiJzIn0seyJjaGFyIjoiZSJ9LHsiY2hhciI6InQifSx7ImNoYXIiOiIgIn0seyJjaGFyIjoiYyJ9LHsiY2hhciI6ImwifSx7ImNoYXIiOiJpIn0seyJjaGFyIjoibiJ9LHsiY2hhciI6ImkifSx7ImNoYXIiOiJjIn0seyJjaGFyIjoiYSJ9LHsiY2hhciI6ImwifSx7ImNoYXIiOiIgIn0seyJjaGFyIjoiZCJ9LHsiY2hhciI6ImUifSx7ImNoYXIiOiJtIn0seyJjaGFyIjoi。 ZSJ9LHsiY2hhciI6Im4ifSx7ImNoYXIiOiJ0In0seyJjaGFyIjoiaSJ9LHsiY2hhciI6ImEifSx7ImNoYXIiOiLvvIkifSx7ImNoYXIiOiLjgIIifSx7ImNoYXIiOiLmt4AifSx7ImNoYXIiOiLnsokifSx7ImNoYXIiOiLmoLcifSx7ImNoYXIiOiLnuqcifSx7ImNoYXIiOiLogZQifSx7ImNoYXIiOiLlj40ifSx7ImNoYXIiOiLlupQifSx7ImNoYXIiOiLlgYcifSx7ImNoYXIiOiLor7QifSx7ImNoYXIiOiLlkowifSx7ImNoYXIiOiLooYAifSx7ImNoYXIiOiLnrqEifSx7ImNoYXIiOiLlip8ifSx7ImNoYXIiOiLog70ifSx7ImNoYXIiOiLpmpwifSx7I。 mNoYXIiOiLnoo0ifSx7ImNoYXIiOiLkuIAifSx7ImNoYXIiOiLnm7QifSx7ImNoYXIiOiLmmK8ifSx7ImNoYXIiOiLnl7QifSx7ImNoYXIiOiLlkYYifSx7ImNoYXIiOiLnoJQifSx7ImNoYXIiOiLnqbYifSx7ImNoYXIiOiLkuK0ifSx7ImNoYXIiOiLnmoQifSx7ImNoYXIiOiLkuKQifSx7ImNoYXIiOiLkuKoifSx7ImNoYXIiOiLkuLsifSx7ImNoYXIiOiLopoEifSx7ImNoYXIiOiLoh7QifSx7ImNoYXIiOiLnl4UifSx7ImNoYXIiOiLmpoIifSx7ImNoYXIiOiLlv7UifSx7ImNoYXIiOiLjgIIifSx7ImNoYXIiOiLnhLYifSx7ImNoYXIiOiLogIwifS。 x7ImNoYXIiOiLvvIwifSx7ImNoYXIiOiLmipcifSx7ImNoYXIiOiLmt4AifSx7ImNoYXIiOiLnsokifSx7ImNoYXIiOiLmoLcifSx7ImNoYXIiOiLom4sifSx7ImNoYXIiOiLnmb0ifSx7ImNoYXIiOiLmipcifSx7ImNoYXIiOiLkvZMifSx7ImNoYXIiOiLmsrsifSx7ImNoYXIiOiLnlpcifSx7ImNoYXIiOiLkuI0ifSx7ImNoYXIiOiLog70ifSx7ImNoYXIiOiLmlLkifSx7ImNoYXIiOiLlloQifSx7ImNoYXIiOiLpmL8ifSx7ImNoYXIiOiLlsJQifSx7ImNoYXIiOiLojKgifSx7ImNoYXIiOiLmtbcifSx7ImNoYXIiOiLpu5gifSx7ImNoYXIiOiLnl4U。 ifSx7ImNoYXIiOiIoIn0seyJjaGFyIjoiQSJ9LHsiY2hhciI6IkQifSx7ImNoYXIiOiIpIn0seyJjaGFyIjoi5oKjIn0seyJjaGFyIjoi6ICFIn0seyJjaGFyIjoi55qEIn0seyJjaGFyIjoi6K6kIn0seyJjaGFyIjoi55+。 lIn0seyJjaGFyIjoi5YqfIn0seyJjaGFyIjoi6IO9In0seyJjaGFyIjoi77yMIn0seyJjaGFyIjoi5ZCMIn0seyJjaGFyIjoi5qC3In0seyJjaGFyIjoi77yMIn0seyJjaGFyIjoi6KGAIn0seyJjaGFyIjoi566hIn0seyJjaGFyIjoi5ZugIn0seyJjaGFyIjoi57SgIn0seyJjaGFyIjoi55qEIn0seyJjaGFyIjoi5o6nIn0seyJjaGFyIjoi5Yi2In0seyJjaGFyIjoi5a+。 5In0seyJjaGFyIjoi5YePIn0seyJjaGFyIjoi6L27In0seyJjaGFyIjoi55e0In0seyJjaGFyIjoi5ZGGIn0。