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Amyloid β (Aβ) deposition is an important pathophysiological feature of Alzheimer's disease (AD) and can be measured in vivo by positron emission tomography (PET)
Studies including the Baltimore Longitudinal Study on Aging (BLSA) have shown that compared with Aβ-negative adults, Aβ-positive adults experience accelerated cognitive decline and are more likely to transition from mild cognitive impairment to AD
Recent PET studies have investigated the relationship between Aβ and gait changes (such as speed, variability), and generally reported an association, indicating that gait may become abnormal with the occurrence and development of AD pathology
Gait may become abnormal with the occurrence and development of AD pathology.
Researchers investigated the cross-sectional relationship between the energy cost of walking, gait speed, and amyloid beta (Aβ) status (+/-) in elderly people.
Linear regression estimates of Aβ status, walking energy expenditure and gait speed in 149 adults (standardized)
Linear regression estimates of Aβ status, walking energy expenditure and gait speed in 149 adults (standardized) Linear regression estimates of Aβ status, walking energy expenditure and gait speed in 149 adults (standardized)The study included 149 cognitively normal adults (56% were women, with an average age of 77.
The results of the study show that for every 0.
For every 0.
The high energy cost of walking is related to AD pathology The high energy cost of walking is related to AD pathology
Original source:
Original source:Ryan J.
Ryan J.
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