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▎WuXi AppTec Content Team Editor As people age, many people not only become less productive at work, but also become less reliable in memory, sensory perception, and bodily functions
.
For example, some elderly people occasionally forget how to go to the most frequently purchased supermarket, cannot remember the names of friends, etc.
In severe cases, they will develop dementia (dementia) including Alzheimer's disease
.
Many of the relatively young population may be dismissive of this, believing it to only happen in older people
.
However, a review analysis published in the journal JAMA Neurology noted that while dementia is more common among older adults, the age-standardized incidence rate shows that globally there are approximately 119 per 100,000 people aged 30-64.
Suffering from dementia! Worldwide, up to 3.
9 million people under the age of 65 may be affected
.
"Diagnosis of dementia at a young age is particularly frustrating because it affects those in the prime of life," David S.
individuals
.
Many people afflicted by symptoms of the disease are in their mid-career 40s and 50s, not ready to retire, and perhaps still raising a family
.
” Early symptoms of dementia are not obvious, so diagnosis is especially difficult, especially when in younger patients
.
Therefore, a thorough cognitive assessment of a patient's memory and language problems is crucial, and neuropsychological tests can detect subtle effects on memory, vision, cognition, and executive function
.
In addition, the patient will need a brain scan to rule out the possibility of the tumor causing the patient's cognitive symptoms
.
Spinal tap and spinal fluid analysis can indicate elevated levels of tau and beta-amyloid in the brain
.
Magnetic resonance imaging (MRI) can show atrophy in specific parts of the brain
.
Glucose positron emission scans (PET), on the other hand, can find abnormal patterns of sugar uptake in various parts of the brain to help distinguish between different types of dementia
.
Many younger patients report symptoms of mental fog (which manifests as memory loss, difficulty concentrating, confusion, etc.
), but many doctors struggle to make an accurate diagnosis of dementia because they can't be sure if it's attributable, he said.
The effects of stress, depression or anxiety, or simply the result of normal aging
.
Since the diagnosis of young-onset dementia is often delayed and treatment options are limited, this is a concern
.
Especially a few months ago, by analyzing nearly 2.
8 million patient data, the Dutch team found that the "younger" distribution of dementia is far more severe than people thought! Globally, 1.
1 people in the 30-34 age group have dementia for every 100,000 people, compared with 77.
4 in the 60-64 age group, but on average 119 people in the 30-64 age group have the disease! Dementia includes Alzheimer's disease, vascular dementia, Lewy body disease, and frontotemporal dementia
.
Alzheimer's disease is the main type of dementia, accounting for 60%-70%
.
Overall, Alzheimer's disease remains the most common type of young-onset and senile-onset dementia, research shows
.
Patients have abnormal deposits of tau and beta amyloid in their brains
.
Image credit: 123RF But when symptoms occur before age 50, vascular dementia and frontotemporal dementia are more common types of young-onset dementia than early-onset Alzheimer's disease
.
In patients with vascular dementia, blood circulation is blocked due to blockage or damage of blood vessels in the brain and brain, resulting in a lack of oxygen and nutrients in the brain
.
In addition to memory problems, the most common symptoms of the disease include confusion, difficulty concentrating, difficulty performing tasks, and slowed thinking
.
Frontotemporal dementia often first appears between the ages of 40 and 64 and can be misdiagnosed as a psychiatric problem
.
The part of the brain located behind the forehead and ears is atrophied, and the onset is characterized by dramatic personality changes, inappropriate social or impulsive behavior, emotional apathy, and motor and memory problems later in the disease
.
Dementia with Lewy bodies is another type of young-onset dementia caused by abnormal deposits of alpha-synuclein in the brain
.
Most of the symptoms are similar to other dementias, and other symptoms include autonomic dysfunction, delusions and non-visual hallucinations, and violent dreams
.
The researchers concluded that although the 119 per 100,000 figure was higher than estimated, the actual incidence of young-onset dementia may be higher
.
This research should be brought to the attention of policy makers and health care professionals to provide more and better clinical care options for this group
.
Reference: [1] Hendriks, S.
, et, al.
(2021).
Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis, JAMA Neurol.
78(9):1080-1090.
doi: 10.
1001 /jamaneurol.
2021.
2161 [2] When Dementia Strikes at an Early Age.
Retrieved January 17, 2022, from https:// html[3] Knopman, DS (2021).
Young-Onset Dementia—New Insights for an Underappreciated Problem.
JAMA Neurology, 78(9), 1055.
https://doi.
org/10.
1001/jamaneurol.
2021.
1760
.
For example, some elderly people occasionally forget how to go to the most frequently purchased supermarket, cannot remember the names of friends, etc.
In severe cases, they will develop dementia (dementia) including Alzheimer's disease
.
Many of the relatively young population may be dismissive of this, believing it to only happen in older people
.
However, a review analysis published in the journal JAMA Neurology noted that while dementia is more common among older adults, the age-standardized incidence rate shows that globally there are approximately 119 per 100,000 people aged 30-64.
Suffering from dementia! Worldwide, up to 3.
9 million people under the age of 65 may be affected
.
"Diagnosis of dementia at a young age is particularly frustrating because it affects those in the prime of life," David S.
individuals
.
Many people afflicted by symptoms of the disease are in their mid-career 40s and 50s, not ready to retire, and perhaps still raising a family
.
” Early symptoms of dementia are not obvious, so diagnosis is especially difficult, especially when in younger patients
.
Therefore, a thorough cognitive assessment of a patient's memory and language problems is crucial, and neuropsychological tests can detect subtle effects on memory, vision, cognition, and executive function
.
In addition, the patient will need a brain scan to rule out the possibility of the tumor causing the patient's cognitive symptoms
.
Spinal tap and spinal fluid analysis can indicate elevated levels of tau and beta-amyloid in the brain
.
Magnetic resonance imaging (MRI) can show atrophy in specific parts of the brain
.
Glucose positron emission scans (PET), on the other hand, can find abnormal patterns of sugar uptake in various parts of the brain to help distinguish between different types of dementia
.
Many younger patients report symptoms of mental fog (which manifests as memory loss, difficulty concentrating, confusion, etc.
), but many doctors struggle to make an accurate diagnosis of dementia because they can't be sure if it's attributable, he said.
The effects of stress, depression or anxiety, or simply the result of normal aging
.
Since the diagnosis of young-onset dementia is often delayed and treatment options are limited, this is a concern
.
Especially a few months ago, by analyzing nearly 2.
8 million patient data, the Dutch team found that the "younger" distribution of dementia is far more severe than people thought! Globally, 1.
1 people in the 30-34 age group have dementia for every 100,000 people, compared with 77.
4 in the 60-64 age group, but on average 119 people in the 30-64 age group have the disease! Dementia includes Alzheimer's disease, vascular dementia, Lewy body disease, and frontotemporal dementia
.
Alzheimer's disease is the main type of dementia, accounting for 60%-70%
.
Overall, Alzheimer's disease remains the most common type of young-onset and senile-onset dementia, research shows
.
Patients have abnormal deposits of tau and beta amyloid in their brains
.
Image credit: 123RF But when symptoms occur before age 50, vascular dementia and frontotemporal dementia are more common types of young-onset dementia than early-onset Alzheimer's disease
.
In patients with vascular dementia, blood circulation is blocked due to blockage or damage of blood vessels in the brain and brain, resulting in a lack of oxygen and nutrients in the brain
.
In addition to memory problems, the most common symptoms of the disease include confusion, difficulty concentrating, difficulty performing tasks, and slowed thinking
.
Frontotemporal dementia often first appears between the ages of 40 and 64 and can be misdiagnosed as a psychiatric problem
.
The part of the brain located behind the forehead and ears is atrophied, and the onset is characterized by dramatic personality changes, inappropriate social or impulsive behavior, emotional apathy, and motor and memory problems later in the disease
.
Dementia with Lewy bodies is another type of young-onset dementia caused by abnormal deposits of alpha-synuclein in the brain
.
Most of the symptoms are similar to other dementias, and other symptoms include autonomic dysfunction, delusions and non-visual hallucinations, and violent dreams
.
The researchers concluded that although the 119 per 100,000 figure was higher than estimated, the actual incidence of young-onset dementia may be higher
.
This research should be brought to the attention of policy makers and health care professionals to provide more and better clinical care options for this group
.
Reference: [1] Hendriks, S.
, et, al.
(2021).
Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis, JAMA Neurol.
78(9):1080-1090.
doi: 10.
1001 /jamaneurol.
2021.
2161 [2] When Dementia Strikes at an Early Age.
Retrieved January 17, 2022, from https:// html[3] Knopman, DS (2021).
Young-Onset Dementia—New Insights for an Underappreciated Problem.
JAMA Neurology, 78(9), 1055.
https://doi.
org/10.
1001/jamaneurol.
2021.
1760
