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    Home > Active Ingredient News > Endocrine System > Alzheimers Res Ther: The relationship between antidiabetic drugs and the scores of simple mental status examination in patients with diabetes and dementia

    Alzheimers Res Ther: The relationship between antidiabetic drugs and the scores of simple mental status examination in patients with diabetes and dementia

    • Last Update: 2021-12-26
    • Source: Internet
    • Author: User
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    Background: Diabetes is a complex risk factor for cognitive deterioration and a common complication of dementia
    .


    In addition, multiple anti-diabetic drugs have been evaluated in random and observational settings to determine their possible cognitive properties


    Diabetes is a complex risk factor for cognitive deterioration and a common complication of dementia


    Results: Compared with untreated patients, long-term users of metformin (β0.
    89, 95%CI 0.
    44; 1.
    33) and DPP-4i (0.
    72, 0.
    06; 1.
    37) had slower cognitive decline over time
    .


    Secondly, compared with DPP-4i, the MMSE using insulin (−1.


    Table 1 The annual point change of the simple mental status examination scores after dementia is related to the use of anti-diabetic drugs

    Table 1 The annual point change of the simple mental status examination scores after dementia is related to the use of anti-diabetic drugs

    Table 2 Comparison of non-metformin hypoglycemic drugs and changes in annual mental status examination scores

    Table 2 Comparison of non-metformin hypoglycemic drugs and changes in annual mental status examination scores

    Figure 1 Linear changes in the MMSE scores of patients with dementia and diabetes are related to exposure to metformin, DPP-4i, insulin, and sulfonylureas
    .


    Figures are based on weighted universal user analysis, DPP-4i, dipeptidyl peptidase-4 inhibitor, CI, confidence interval, MMSE, simple mental status check, one year represents the time after baseline, and the thin line represents individual subjects ( Circle) Simple mental state change in time, the thick line represents the estimated simple mental state change derived from the mixed model

    Figure 1 Linear changes in the MMSE scores of patients with dementia and diabetes are related to exposure to metformin, DPP-4i, insulin, and sulfonylureas


    In this large group of patients with diabetes and dementia, the use of metformin and DPP-4i is associated with a slower decline in MMSE scores


    Secnik J, Xu H, Schwertner E, et al.


    he association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia.
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