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Background: Diabetes is a complex risk factor for cognitive deterioration and a common complication of dementia
.
In addition, multiple anti-diabetic drugs have been evaluated in random and observational settings to determine their possible cognitive properties
Diabetes is a complex risk factor for cognitive deterioration and a common complication of dementia
Results: Compared with untreated patients, long-term users of metformin (β0.
89, 95%CI 0.
44; 1.
33) and DPP-4i (0.
72, 0.
06; 1.
37) had slower cognitive decline over time
.
Secondly, compared with DPP-4i, the MMSE using insulin (−1.
Table 1 The annual point change of the simple mental status examination scores after dementia is related to the use of anti-diabetic drugs
Table 1 The annual point change of the simple mental status examination scores after dementia is related to the use of anti-diabetic drugsTable 2 Comparison of non-metformin hypoglycemic drugs and changes in annual mental status examination scores
Table 2 Comparison of non-metformin hypoglycemic drugs and changes in annual mental status examination scoresFigure 1 Linear changes in the MMSE scores of patients with dementia and diabetes are related to exposure to metformin, DPP-4i, insulin, and sulfonylureas
.
Figures are based on weighted universal user analysis, DPP-4i, dipeptidyl peptidase-4 inhibitor, CI, confidence interval, MMSE, simple mental status check, one year represents the time after baseline, and the thin line represents individual subjects ( Circle) Simple mental state change in time, the thick line represents the estimated simple mental state change derived from the mixed modelFigure 1 Linear changes in the MMSE scores of patients with dementia and diabetes are related to exposure to metformin, DPP-4i, insulin, and sulfonylureas
In this large group of patients with diabetes and dementia, the use of metformin and DPP-4i is associated with a slower decline in MMSE scores
Secnik J, Xu H, Schwertner E, et al.
he association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia.
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