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Subjective cognitive decline (SCD) , that is, the cognitive deterioration that is perceived in clinical evaluation, but there is no obvious performance problem, may be an important precursor of dementia.
Subjective cognitive decline (SCD) , that is, the cognitive deterioration that is perceived in clinical evaluation, but there is no obvious performance problem, may be an important precursor of dementia.
The experiment studied three functional connectivity trajectories measured at an interval of about 18 months, using a voxel implicit growth model, and using different subjective cognitive decline self-reports in cognitively unimpaired elderly people (N = 69) .
A series of longitudinal analyses were performed to determine changes in brain function in the resting state of SCD and how changes in brain function are related to cognitive performance.
Longitudinal functional connectivity analysis method.
Baseline MFQ-FoF predictive communication between the reduced cortical left dorsal hippocampus and the medial prefrontal, 248mm .
Baseline MFQ-FoF predictive communication between the reduced cortical left dorsal hippocampus and the medial prefrontal, 248mm .
Baseline MFQ-FoF predicts that the connectivity between the left hippocampus and the sulcus and lingual gyrus decreased, and the cluster range was 584 mm 3 .
Baseline MFQ-FoF predicts that the connectivity between the left hippocampus and the sulcus and lingual gyrus decreased, and the cluster range was 584 mm 3 .
Baseline MFQ-FoF predicts that the connection between the right hippocampus and the dorsal medial prefrontal cortex is reduced, and the cluster size is 312 mm 3
Baseline MFQ-FoF predicts that the connection between the right hippocampus and the dorsal medial prefrontal cortex is reduced, and the cluster size is 312 mm 3 3The baseline MFQ-FoF was positively correlated with the FC slope of the left dorsal anterior insula and dorsal medial prefrontal cortex.
The baseline MFQ-FoF was positively correlated with the FC slope of the left dorsal anterior insula and dorsal medial prefrontal cortex.
Baseline MFQ-FoF predicts increased connectivity between the dorsal side of the left anterior insula and the extra cortex of the left orbit, with a size of 3 clusters of 248 mm .
Baseline MFQ-FoF predicts increased connectivity between the dorsal side of the left anterior insula and the extra cortex of the left orbit, with a size of 3 clusters of 248 mm .
Individuals with a higher degree of subjective cognitive decline have lower connectivity between the components of the default network, and higher connectivity between the significant network and the components of the default network.
The current analysis assesses the longitudinal FC and cognitive trajectories of elderly people with varying degrees of subjective cognitive decline.
Subjective cognitive decline is a hypothetical precursor of dementia, characterized by perceptual deficits in cognitive ability, but it has not been confirmed by formal evaluations.
Original source
Viviano, RP, Damoiseaux, JS Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline.
Alz Res Therapy 13, 108 (2021).
https://doi.
org/10.
1186/s13195-021-00847-y
Alz Res Therapy 13, 108 (2021).
https://doi.
org/10.
1186/s13195-021-00847-y Viviano , RP, Damoiseaux, JS Longitudinal change in hippocampal and dorsal anterior insulae functional connectivity in subjective cognitive decline.
Alz Res Therapy 13, leave a message here
