Am J Clin Nutr: DHA intake may be beneficial to people with high genetic risk of AD

Alzheimer's disease (AD) causes a huge socioeconomic burden.

To determine this, self-reported dietary intake of DHA was evaluated and tested in APOE-ε4 carriers (n=122, non-carriers; n=157, 1 allele; n=61, 2 alleles In a population rich in genes, look for neuropsychological tests (contextual memory and executive function), magnetic resonance markers of cerebral small vessel disease (WMHs and CMBs), and early AD-related neurodegeneration (cortical thickness in AD vulnerable areas) Correlation.

Among 340 subjects in the Alzheimer's disease (Alzheimer's disease and family) study, APOE-ε4 carriers (n=122, non-carriers; n=157, 1 allele) were assessed by FFQ ; N=61, 2 alleles) self-reported DHA intake.

A D A scatter plot of the relationship between self-reported DHA dietary intake and normalized residues of cortical thickness.

Three aspects of the results of this study are worth highlighting.

In summary, in middle-aged cognitively normal individuals with increased genetic risk of sporadic AD, self-reported dietary DHA was found to be associated with several beneficial cerebrovascular pathologies or neuroimaging phenotypes associated with AD-related neurodegeneration.

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