Postoperative inflammatory responses contribute to tissue healing and recovery, but excessive inflammation is associated with postoperative complications, and n-3 (oh-3) PUFAs regulate the inflammatory response and may help prevent pro-inflammatory cascades.
study to explore the effects of intravenous n-3 PUFAs during perioperative period on inflammatory cytokines in colon cancer surgery.
study is a randomized, double-blind, placebo-controlled clinical trial.
44 patients who underwent selective colonectomy with non-metastatic cancer, were randomly assigned to two intravenous n-3 PUFA or physiological saline controls on the eve of surgery and on the morning after surgery.
blood samples were taken at 6 perioperative time points to understand the changes in cytokines in the serum and the whole blood samples and the fatty acid spectrum of the leukocyte membranes stimulated by LPS.
results, 23 patients received physiological saline and 21 patients received n-3 PUFAs.
except for open cuts, patients and surgery in each group have the same characteristics (physiological saline n snalinity n s 5, n-3 PUFA n s 0, P s 0.056).
in vitro IL-6 after LPS stimulation increased significantly in the n-3 PUFA group on the first day after surgery (P - 0.014), but there was no difference on the second day after surgery (P - 0.467).
the 4th day after surgery, the white blood cell count in the n-3 PUFA group was higher (P - 0.029). more patients in the
n-3 PUFA group developed infectious complications (8 vs 3 cases, P - 0.036). there was no overall difference in serum IL-6, IL-10, C reactive protein, and hospital time in
giving n-3 PUFAs can increase the level of white blood cell membrane n-3 PUFAs rapidly.
in general, the results showed no significant correlation with serum and LPS-stimulated cytokines in the n-3 PUFA group, but unexpectedly, more infectious complications occurred.
, therefore, in the scope of this study, the intravenous injection of n-3 PUFA emulsions during perioperative period as an independent infusion in the non-standard use of colonectomy in primary conjugation needs to be carefully used.