Am J Clin Nutr: Intestinal response to dietary lipids in patients with gastric bypass surgery

Changes in dietary-related intestinal hormone secretion seem to be important for weight loss and diabetes relief after Roux-en-Y gastric bypass (RYGB).
the dietary ingredients and subjects that play a role can help identify new treatments for obesity and diabetes.
endocrine cells react to the digestive products of dietary triglycerides, especially long-chain fatty acids (LCFAs) and 2-oilyl glycerin (2-OG) rather than medium-chain fatty acids (MCFAs).
In an exploratory random cross-design, we looked at olive oil (20 ml) and its derivatives, LCFAs and 2-OG to RYGB surgery and intestinal endocrine in unscathed participants . . . insulin peptide-1 (GLP-1), The effects of glucose-dependent insulin peptides (GIP), gallbladder systolics (CCK), peptides YY (PYY) and neurotensin (NT), as well as the metabolism of glucose, lipids and bile acids, have been published online in Am J Clin Nutr.
study included 10 RYGB surgical patients and 10 matching control groups who ate three isomolar triglyceride formulations on different days: olive oil (digestion 2-OG plus LCFAs), C8-food oil (2-OG plus MCFAs) and triglycerides (MCFAs; negative control).
hormone response is calculated using the area between the lower curve (AUC).
results showed that, regardless of group status, olive oil to plasma GLP-1 (-32%; 95% CI: 23%, 43% ;P<0.01), CCK (-53%, P<0.01< ) and NT (-71%, P<0.01) have a greater AAUC effect, while the effect on the GIP varies from group to group (control group plus 90%, P<0.01; RYGB group plus 24%, P s 0.10).
not taking into account the group status, the effect of C8-dietary oil on plasma CCK (-40%, P<0.01) and NT (-32%, P<0.01) was greater than that of triceps, but had little effect on GLP-1. 95% CI: -2.9%, 13% ;P s 0.22), and the effect on the GIP varies from group to group (control group s 78%, P<0.01; RYGB s 39%, P s 0.01).
endocrine response was generally greater than that of the control group in RYGB patients with far-end (GLP-1/PYY/NT) rather than near-end (CCK/GIP).
, the results showed that LCFAs combined 2-OG was much more effective than 2-OG combined MCFAs in stimulating intestinal endocrine in RYGB postoperative and matching control group individuals.
release of intestinal hormones induced by distant lipids after RYGB surgery.
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