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Multivitamin and mineral supplements (MVMs) typically provide ≥100% of the recommended daily intake of the most basic vitamins and minerals and are the most common dietary supplements in the United States and other high-income countries
.
Depending on the ingredients and purpose, MVMs can be divided into daily MVMs, potent MVMs, and dedicated MVMs
Multivitamin and mineral supplements (MVMs) typically provide ≥100% of the recommended daily intake of the most basic vitamins and minerals and are the most common dietary supplements in the United States and other high-income countries
This was a randomized, double-blind, placebo-controlled, 2x2 factorial clinical trial of 21,442 U.
S.
adults (12,666 women ≥65 years and 8776 men ≥60 years) with no significant Cardiovascular disease and cancer
.
Daily MVM and cocoa extract interventions were randomized between June 2015 and December 2020
Incidence of aggressive cancer in both groups
Incidence of aggressive cancer in both groupsAt 3.
6 years of follow-up, 518 subjects in the MVM group and 535 subjects in the placebo group developed invasive cancer (hazard ratio [HR] 0.
97, p=0.
57)
.
Taking daily MVM had no significant effect on the risk of breast and colorectal cancer (HR 1.
There were 518 and 535 subjects in the MVM and placebo groups, respectively, who developed aggressive cancer (hazard ratio [HR] 0.
Cardiovascular disease hazard ratio between the two groups
Cardiovascular disease hazard ratio between the two groupsThe composite cardiovascular disease endpoint (HR 0.
98) occurred in 429 and 437 subjects in the MVM and placebo groups, respectively
.
In addition, daily MVM failed to significantly affect all-cause mortality (HR 0.
Daily MVM failed to significantly affect all-cause mortality (HR 0.
Compared with placebo, routine daily MVM supplementation reduced lung cancer risk in older adults, but not overall cancer risk and had no significant effect on cardiovascular disease risk
Original source:
Original source:Sesso Howard D, Rist Pamela M, Aragaki Aaron K et al.
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