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    Home > Active Ingredient News > Infection > Am J Clinical Patho: Northwestern University School of Medicine: COVID-19 can damage a pregnant woman's placenta and may have an effect on the fetus

    Am J Clinical Patho: Northwestern University School of Medicine: COVID-19 can damage a pregnant woman's placenta and may have an effect on the fetus

    • Last Update: 2020-06-24
    • Source: Internet
    • Author: User
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    Introduction: The effects of severe acute respiratory syndrome (SARS-CoV-2) and related coronavirus COVID-19 on pregnant women and infants are of particular concern to obstetricians, pediatricians and patientsA study published May 22 in the American Journal of Clinical Pathology at Northwestern University School of Medicine suggests that COVID-19 can damage a pregnant woman's placenta and may have an effect on the fetusAccording to a new report from the University of Northwestern School of Medicine, pathological tests conducted immediately after delivery of a fetus showed signs of placenta damage in the placenta of 16 women who tested positive for COVID-19 during pregnancythe type of damage seen in the placenta indicates an abnormal blood flow between the mother and the fetus in the womb, indicating new complications of COVID-19This finding helps inform how pregnant women are clinically monitored during pandemicsthe study, published May 22 in the American Journal of Clinical Pathology, is the largest study of placental health in women who tested positive for COVID-19Pregnant women and fetuses need to be more closely monitored
    the 16 women in thestudy were born at the Prentice Women's Hospital of Northwestern Medical College, all of whom tested positive for COVID-19, and four patients who developed flu-like symptoms 3-5 weeks before giving birth and tested positive for the virusThe other women tested positive for the virus when they came to give birth, five of whom had no symptoms, while the other seven women developed SYMPTOMs of COVID-19 when they came to give birth16 women's medical history16 women's disease progression30 to 40 women give birth every day at Prentice Women's Hospital, and the team began testing the placenta of COVID-19-positive women early in AprilIn the study, 14 live babies were born full-term, with normal weight and abbys scores, and one baby was born prematurely"Most of these babies give birth after a full-term month of normal pregnancy, so you don't normally expect any problems with the placenta, but the virus seems to cause some damage to the placenta," said DrJeffrey Goldstein, an assistant professor of pathology at Northwestern University Feinberg School of Medicine in and a senior author of the study Based on our limited data, the virus does not appear to cause negative outcomes in live births, but the data do confirm the view that women infected with COVID-19 should be monitored more closely a selection of pathology from patients with new coronavirus diseases A maternal atherosclerosis and fibrin-like necrosis (x 20) B, fetal fluff small lesions with lymphocyte fluffitis (x 20) C, fluff blood clots are Zahn line (x 5) D Fetal fluff has fluffy blood vessel hyperplasia and edema (x 40) Emily Miller, an assistant professor of obstetrics and gynecology at Feinberg and an obstetrician at Northwestern University and a co-author of the study, said the enhanced monitoring could take the form of non-stress tests, which check the placenta's oxygen delivery, or grow ultrasounds to test whether the baby is growing at a healthy rate "These babies are healthy, full-year, beautiful, normal babies, but our findings suggest that many blood streams are blocked, many placentas are smaller than normal placentas, placenta is built with a lot of redundancy, even if only half works, the baby is usually fine, and although most babies are better, they are still at risk of being damaged during pregnancy," said Miller "It's not sensational, " says Miller I don't want to draw a comprehensive conclusion from a small study, but preliminary studies on how COVID-19 causes placental changes are of considerable importance to pregnancy health We have to discuss whether we should change the way pregnant women are currently monitored "
    the effects of previous influenza people often compare the current COVID-19 pandemic to influenza, and previous studies have found that children in the womb have lower lifetime incomes and a higher incidence of cardiovascular disease during the 1918-19 influenza pandemic The flu doesn't pass through the placenta, so life-long problems are likely to be caused by immune activity and placental damage, Mr Golds said "Our research and other similar studies are trying to provide a factual basis for this finding so that we can consider what research questions we should ask these children and what we can or should do now to mitigate these results," said Goldz 15 women gave birth at the ninth month, but one woman miscarried in the middle of pregnancy, Mr Goldz said We also identified four other miscarriages in COVID-19 patients, all of which had symptoms, and three of the four patients had severe placental inflammation, and I wanted to know more before reaching any conclusions "
    the role of the placenta and abnormal placenta is the first organ formed in the development of the fetus, it acts as the lung, intestine, kidney and liver of the fetus, absorbs oxygen and nutrients from the mother's blood and exchanges waste The placenta also causes many hormonal changes in the mother's body Examining a woman's placenta allows the pathologist to follow a retrospective road map of the woman's pregnancy in order to understand the condition of the fetus in the womb or the mother and baby after birth "The placenta is the equivalent of a ventilator for a fetus, and once the placenta is damaged, there are terrible consequences," said Miller There are two common abnormalities in the placenta in these patients: insufficient blood flow from the mother to the fetus, vascular abnormalities (also known as insufficient maternal vascular perfusion (MVM), and blood clots in the placenta (also known as fluffy interstitial thrombosis) in cases of insufficient vascular perfusion, the mother's blood pressure was higher than normal This condition usually occurs in women with preeclampsia and high blood pressure Interestingly, only one in 15 women in the study had preeclampsia or high blood pressure a new consensus
    in February, before the pandemic reached Chicago, Mr Goldz organized his research team "If you're infected with the flu and you're pregnant, we don't know anything about what's going on in your placenta, so we're starting to look at how we're going to study this flu-like epidemic if the new coronavirus arrives in Chicago," Golds said In case the pandemic comes, we'll be ready "There has been a new consensus that there is a problem with clotting and vascular damage in patients with COVID-19, and our findings support the possibility that the coronavirus may form some kind of clot, and this happens in the placenta," said the study showed that both pregnant women and fetuses needed to be tested more closely, and that the placenta of pregnant women who had tested positive for THE COVID-19 virus did have damage, which is likely to have an effect on the fetus
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