Am J Emerg Med: The efficacy of ampicillin in the treatment of brain injury.

Meamincyclic acid has a certain therapeutic effect on traumatic brain injury.
system review and meta-analysis aimed at studying the efficacy of ampicillin in the treatment of traumatic brain injury.
researchers systematically searched the Library databases of PubMed, EMbase, Web of Science, EBSCO, and Cochrane, and collected randomized controlled trials (RCTs) on the efficacy of ampicillin in the treatment of traumatic brain injury. A total of 6 RCTs were included in the results of the
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compared to the placebo group, in patients with traumatic brain injury, meaminic acid can significantly reduce mortality (risk ratio (RR) s 0.91; 95% confidence interval (CI) s 0.85 to 0.97; P -0.004) and hemorrhagic lump growth (RR-0.78; 95% CI-0.61 to 0.99), but surgery (0.04), but 99; 95% CI - 0.85 to 1.15; P - 0.92), extracranial surgery (RR s 1.00; 95% CI s 0.97 to 1.04; P - 0.99), bad outcome (Glasgow results scale, GOS) RR (0. 72; 95% CI - 0.47 to 1.11; P - 0.14), pulmonary embolism (1.86; 95% CI - 0.42 to 8.29; P - 0.42) and deep vein thrombosis (RR - 0.97; 95% CI - 0.64 to 1.47; P RR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
in general, the results showed that meamincyclic acid was associated with significantly reduced mortality and growth of hemorrhagic lumps in patients with traumatic brain injury, but the need for neurosurgery and extracranial surgery and the risk of adverse outcomes (GOS) were similar between ampicillin and placebo.
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