Am J Epidemiol: Sensitive screening methods early detection of lung cancer may lead to additional thyroid tumors.

Advances in cancer screening methods have opened the way for accidental discovery and overdiagnosis of cancer.
We conducted a second analysis of the National Lung Screening Trial (registered 2002-2004), a randomized controlled trial that compared low-dose computerized fault scans (LDCT; n s 26,722) and chest X-ray photography (CXR; n s 26,732) to detect lung cancer to detect accidental findings related to thyroid cancer (ThCa).
study included three rounds of screening, with a medium follow-up time of 6.6 years for LDCT and 6.5 years for CXR.
radiologists reported lung and non-lung-related abnormalities.
In baseline, year 1 and year 2, 5.7 percent, 4.7 percent, and 4.5 percent of participants in the LDCT group detected abnormalities above the shin muscle (AADs), while the CXR group detected abnormalities above the muscle (AADs), while the CXR group detected 2.3 percent, 1.5 percent, and 1.3 percent, respectively.
the LDCT group, 205 AADs (7.0%) were associated with the thyroid gland.
, 60 ThCas, 35 LDCT and 25 CXR (P-0.2) were studied.
LDCT group, participants with previous AAD had a 7.8-fold increased risk of ThCa (95% confidence interval: 4.0, 15.1) compared to participants without AAD.
ThCas early and persistent overdoses diagnosed earlier in the LDCT group suggest overdiagnosis.
early detection of lung cancer using sensitive screening methods may be accompanied by the discovery of thyroid tumors.
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