Am J Gastroenterol: Electrodynamic drug therapy can effectively treat children's intractable constipation

Chronic constipation can manifest as painful defecation, fecal impaction, fecal overflow, and Hirschsprung's disease.

Researchers from Iran conducted a randomized trial to evaluate the effect of intrarectal injection of botulinum toxin A/electrokinetic drugs (BoNTA/EMDA) on children with constipation, and compared the effect with conventional intrathecal injection of BoNTA The results have been published in Am J Gastroenterol.

From 2017 to 2019, researchers enrolled 60 children with intractable constipation aged 5-13 who met Rome III criteria and were randomly assigned to 2 treatment groups: the EMDA group (n = 30) received BoNTA/EMDA and the control group (n = 30) Accepted BoNTA injection into the internal anal sphincter.

The results showed that after 1 month of follow-up, the number of patients in the EMDA group (24/30, 80%) and the injection group (25/30, 83.

In summary, the results of the study indicate that BoNTA/EMDA seems to be as effective as intrathecal injection of BoNTA in the treatment of refractory constipation.

Original source:

Abdol-Mohammad Kajbafzadeh, Lida Sharifi-Rad, et al.