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Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 has spread worldwide and there are no proven treatments.
rehabilitation plasma therapy has been used to treat serious microbial infections for more than 100 years and has been successful to varying degrees.
from March 28, 2020 to April 14, 2020, researchers recruited patients with severe and/or life-threatening COVID-19 diseases at Houston Methodist Hospital (n s 25).
patients infuse plasma during the rehabilitation period, from the confirmed severe acute respiratory syndrome coronavirus 2 infection during the recovery period of plasma.
results of the study were safety, with the secondary result being clinical status on the 14th day after blood transfusion.
to assess patient clinical improvement based on improved WHO six-point sequence tables and laboratory parameters.
virus genome sequences were performed on the supply and receptor strains.
results showed that on the 7th day after the infusion of plasma from the rehabilitation period, the clinical score of nine patients improved by at least 1 point, of which 7 patients were discharged from the hospital.
14 days after the blood transfusion, 19 (76%) patients had at least one improvement in their clinical status, 11 of whom were discharged from the hospital.
no adverse events caused by blood transfusions have been observed.
genome-wide sequencing data did not find a correlation between strain genotypes and disease severity.
, the results show that for patients with COVID-19 severe illness, plasma during infusion and rehabilitation is a safe treatment.
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