Am J Psychiatry prevention and treatment of substance use disorders can reduce mortality in patients with eating disorders

Eating disorders are associated with high mortality
.

Anorexia nervosa (AN) is the second leading cause of death in mental illness, after substance use disorder (SUD)

Angelina Isabella Mellentin et al.
evaluated the relationship between alcohol use disorder and other SUDs and mortality from anorexia nervosa, bulimia nervosa, and unspecified eating disorders, and compared them with matched control subjects
.

Angelina Isabella Mellentin et al.
evaluated the relationship between alcohol use disorder and other SUDs and mortality from anorexia nervosa, bulimia nervosa, and unspecified eating disorders, and compared them with matched control subjects
.

The study included 20,759 patients with eating disorders and 83,036 matched control subjects
.

The hazard ratio was calculated to compare the risk of all-cause death between patients with eating disorders and the control group (including with and without lifelong SUD diagnosis (abuse or dependence on alcohol, marijuana, or hard drugs))

diagnosis

The adjusted risk ratios to alcohol and/or marijuana abuse (anorexia nervosa, bulimia nervosa, and unspecified eating disorders) were 11.
28 [95% CI=7.
01, 18.
16], 5.
86 [95% CI=3.
37, 10.
1, respectively ] And 10.
86 [95% CI=6.
74, 17.
50]), or a SUDs-free control using addictive drugs alone or in combination with alcohol and/or marijuana (95% CI = 2.
43, 4.
23), 1.
24 (95% CI = 0.
88, 1.
77), compared with 4.
75 (95% CI = 3.
57, 6.
31)), patients with each type of eating disorder have a higher risk of all-cause death
.

Compared with control subjects without SUDs, control subjects with SUDs also showed an increased risk of all-cause mortality, although the degree was much lower than that of patients with SUDs eating disorders

The adjusted risk ratios to alcohol and/or marijuana abuse (anorexia nervosa, bulimia nervosa, and unspecified eating disorders) were 11.

SUDs have an additional effect on the additional mortality of patients with eating disorders

Mellentin AI, Mejldal A, Guala MM, et al.

Mellentin AI, Mejldal A, Guala MM, et al.
The Impact of Alcohol and Other Substance Use Disorders on Mortality in Patients With Eating Disorders: A Nationwide Register-Based Retrospective Cohort Study [published online ahead of print, 2021 Oct 26].
Am J Psychiatry.
2021;appiajp21030274.
doi:10.
1176/appi.
ajp.
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