Am J Respir Crit Care Med: Balanced crystals reduce hospitalization in patients with sepsis compared to physiological saline.

Intravenous crystals are the basic treatment for sepsis, but the effect of crystalline composition on patient outcomes remains unclear.
study aims to balance the effects of crystal liquid and physiological saline on 30-day hospitalization mortality in severe adult sepsis patients, the results of the study, published online online in Am J Respir Crit Care Med.
A secondary analysis was conducted on patients in SMART (isoly osmotic solution and major renal adverse event trials) who were admitted to the medical ICU with sepsis coded as sepsis in the 10th edition of the International Classification of Diseases, using multiple regression to control potential conflusion factors.
results, of the 15,802 patients who joined SMART, 1,641 were diagnosed with sepsis and admitted to the medical ICU.
compared to 255 patients (31.2%) in the physiological saline group, a total of 217 patients (26.3%) in the balanced crystal solution group experienced 30 days of in-hospital morbidity (corrected aOR, 0.74; 95% confidence interval (CI), 0.59-0.93; P , 0.01).
of major kidney adverse events occurred within 30 days in patients in the balanced group compared to the physiological saline group (35.4% vs. vs. 40.1%;aOR, 0.78;95% CI, 0.63-0.97), days without boosters (20 ± 12 vs. 19 ± 13; aOR, 1. 19±13; aOR, 1.25; 95% CI, 1.02-1.54) and no kidney replacement treatment days (20±12 vs. 19±13; aOR, 1.35; 95% CI, 1.08-1.69) more.
, the results showed that in patients with sepsis, the use of balanced crystalline fluids reduced the 30-day hospitalization mortality rate compared to the use of physiological saline.
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