Am J Respir Crit Care Med: Procalcitonin can reduce the occurrence of long-term infection-related adverse events in sepsis

Antimicrobial resistance is associated with higher morbidity, mortality, long-term hospitalization, and increased medical costs due to infections caused by multidrug-resistant organisms (MDROs) and Clostridium difficile .

Although early antibiotic discontinuation under the guidance of procalcitonin (PCT) can reduce the use of antibiotics in lower respiratory tract infections, the results of long-term sepsis sequelae are still unclear.

The study included 266 patients with sepsis (as defined by Sepsis-3) with lower respiratory tract infection, acute pyelonephritis or primary bloodstream infection, and they were randomly (1:1) to discontinue antibiotics or standard care under the guidance of PCT .

The results showed that the incidence of infection-related adverse events were 7.

In summary, the results of this study show that in sepsis, PCT guidance can effectively reduce infection-related adverse events, 28-day mortality and hospitalization costs.

Original source:

Evdoxia Kyriazopoulou, Lydia Liaskou-Antoniou, et al.