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American Journal of Psychiatry: Cognitive deficits and hippocampal atrophy in midlife in long-term marijuana users

 Last Update: 2022-04-21
 Source: Internet
 Author: User

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Adolescents and young marijuana users exhibit mild cognitive deficits and differences in brain structure
.

Because young and middle-aged cognitive deficits and more severe hippocampal atrophy are risk factors for later dementia

Adolescents and young marijuana users exhibit mild cognitive deficits and differences in brain structure

Madeline H.

The study recruited 1037 members of a representative cohort born between 1972 and 1973 until age 45 with a 94% retention rate
.

Cannabis use and dependence were assessed at 18, 21, 26, 32, 38 and 45 years of age
.

IQ was assessed at 7, 9, 11 and 45 years of age
.

Specific neuropsychological functions and hippocampal volume were assessed at age 45

IQ was assessed at 7, 9, 11 and 45 years of age

Long-term marijuana users showed a decline in IQ from childhood to middle age (average = -5.

They were absent or smaller in long-term smokers, drinkers, middle-aged recreational marijuana users, and marijuana abstainers

Comparison of childhood IQ, adult IQ, and changes in IQ among long-term marijuana users and five subgroups of children

Cognitive deficits in long-term marijuana users cannot be explained by persistent smoking, alcohol or other illicit drug use, child socioeconomic status, low child self-control, or family history of substance dependence
.

Long-term marijuana users showed smaller hippocampal volumes, but smaller hippocampal volumes did not statistically mediate marijuana-related cognitive deficits
.

Long-term marijuana users showed smaller hippocampal volumes, but smaller hippocampal volumes did not statistically mediate marijuana-related cognitive deficits
.
Long-term marijuana users showed smaller hippocampal volumes, but smaller hippocampal volumes did not statistically mediate marijuana-related cognitive deficits
.
statistics

Long-term marijuana users and hippocampal volume

Long-term marijuana users develop cognitive deficits and smaller hippocampal volumes in midlife
.
Research is needed to determine whether long-term marijuana users exhibit higher rates of dementia later in life
.
Long-term marijuana users develop cognitive deficits and smaller hippocampal volumes in midlife
.
Research is needed to determine whether long-term marijuana users exhibit higher rates of dementia later in life
.

original source

Meier MH, Caspi A, R Knodt A, et al.
Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife [published online ahead of print, 2022 Mar 8].
Am J Psychiatry.
2022;appiajp202121060664.
doi:10.
1176/ appi.
ajp.
2021.
21060664 Meier MH, Caspi A, R Knodt A, et al.
Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife [published online ahead of print, 2022 Mar 8].
Am J Psychiatry.
2022;appiajp202121060664 .
doi:10.
1176/appi.
ajp.
2021.
21060664 Leave a message here

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