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Viagra (Sildenafil, Sildenafil), many people know that it is a drug for the treatment of male erectile dysfunction, but in fact its original use is to treat cardiovascular disease, because it did not meet the researchers' expectations Clinical trials were discontinued for the purpose of dilating blood vessels and relieving cardiovascular disease
.
Megaesophagus , a rare eating disorder that affects the esophagus of many dog breeds to the lungs
.
In severe cases, the disease can lead to aspiration pneumonia, often with dire consequences
megaesophagus
Early literature shows that most dogs with the disease die from aspiration pneumonia within eight months of diagnosis, or are humanely euthanized due to poor quality of life
.
Recently, researchers from Washington State University's College of Veterinary Medicine published an article entitled " A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs " in the American Journal of Veterinary Research .
research paper .
The study suggests that the miracle drug Viagra holds promise for the often fatal form of megaesophagus, with liquid sildenafil shown to relax the smooth muscles of the lower esophagus, opening it up and allowing food to enter the stomach
.
Aside from some rare gastrointestinal irritation, the doses used in the study had no side effects in dogs
In early research, Viagra was once a "god", and multiple studies have shown that Viagra can treat arrhythmias, prevent sudden cardiac death, reduce the risk of heart attack in people with coronary artery disease, and even treat and prevent Alzheimer's disease.
Zheimer's disease
In this randomized crossover study, researchers analyzed 10 dogs with megaesophagus, divided into 2 groups, given a placebo or sildenafil for two weeks
.
Then, let the dogs take no medication for a week
The observations showed that 9 out of 10 dogs ruminated less during the two weeks they received the liquid sildenafil
.
The researchers say it opens the lower esophageal sphincter for 20 minutes to an hour, which is very effective for dogs because we only want them to open it when they eat
.
In addition, the researchers used moving X-rays to examine how the food was swallowed
.
However, there was no significant difference between placebo and sildenafil in the 30-minute video fluoroscopy
On the positive side, sildenafil improved each dog's body weight, with the average dog gaining more than two pounds by the end of the study
.
The researchers said dogs with moderate disease showed the best treatment effects, and less effective in dogs with severe macroesophagus, in which sildenafil is more difficult to get into the animals' stomachs for absorption
.
Taken together, this study found that sildenafil holds promise for the often fatal form of megaesophagus
.
Researchers believe that sildenafil will save the lives of many dogs
Sildenafil will save the lives of many dogs
Original source:
Susan O.
A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs
