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Amgen/BeiGene's new anti-cancer drug approved in China

 Last Update: 2021-08-07
 Source: Internet
 Author: User

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Source: Guanlan Pharmaceutical

According to the latest announcement on the website of China's State Food and Drug Administration, the carfilzomib for injection (carfilzomib, trade name: Kyprolis) jointly developed by Amgen and BeiGene has been officially approved in China

Screenshot source: reference [1]

Proteasomes (proteasomes) in cells can break down damaged or no longer needed proteins, which play an important role in the normal function and growth of cells

In 2016, carfilzomib was approved by the US FDA as a monotherapy or a combination therapy with dexamethasone or dexamethasone + lenalidomide to treat patients with relapsed or refractory MM

In a phase 3 clinical trial called ASPIRE, 792 patients with relapsed or refractory MM received carfilzomib combined with lenalidomide and dexamethasone (KRd) combination regimen or lenalidomide and dexamethasone (Rd) regimen

The test results showed that the average OS of the patients receiving KRd therapy was 48.

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