An accidental discovery by Nature gave us a new understanding of how cells perform multiple tasks

Researchers at the Quantitative Biological Sciences Institute (QBI) at the University of California, San Francisco have discovered a new paradigm that can regulate basic biological switches at the molecular level, that is, they can be turned on and off to control cell differentiation, cell growth, and cells.

The research was published in the October 13th issue of Nature

"This is basic curiosity-driven science

Kortemme’s laboratory focuses on the mechanical details of the individual components of the system, or how all the molecular components in the cell work together.

"When scientists from different disciplines work together, science develops faster," Krogan explained

Multitasking and sensitivity

Molecular switches, such as GTPase Gsp1 used in research, are proteins that play an important role in regulating cell growth and intracellular molecular transport, allowing complex systems to respond to changes in the environment

So far, people think that the central molecular switch can only be adjusted in two different ways, but in fact, once the molecular and system level research is integrated, it is obvious that when you expand from the molecule to the cell, the effect of the protein Gsp1 The perception of change is different

The subtle difference in regulation seems to lie in sensitivity.

In the first article, Dr.

Inspiration from alterations and the future

In addition to sensitivity, another surprising discovery of switching paradigm: how to switch on

The team discovered 4 new allosteric sites in the project, located at positions 34, 141, 147, and 157 of Gsp1

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DOI

10.

Article title

Systems-level effects of allosteric perturbations to a model molecular switch