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Recently, the Shanghai Institute of Applied Physics of the Chinese Academy of Sciences, in collaboration with East China Normal University, made new progress in DNA molecular machines and built an efficient DNA walking robot driven by nucleic acid exoceps.
the realization of many functions within the cells and the operation of machines in the macro world are the same, these natural molecular machines are composed of biological macro-molecules that have evolved over hundreds of millions of years.
the dynamic and orderly structure of cells in test tubes, and the construction of artificial molecular machines has aroused wide interest among researchers.
2016 Nobel Prize in Chemistry was awarded for "Design and Synthesis of Molecular Machines".
dna molecules have strong sequence programmability and precise molecular recognition ability, and are considered to be important components in the design of molecular machines.
design and build efficient DNA molecular machines with significant application potential in areas such as drug transportation therapy, DNA parallel computing, and biometric testing.
, however, in the past synthetic DNA molecular machines tended to have less sustainable cruising capability.
In response to this technical difficulty, Yan Chunhai, a researcher in the Institute of Physical Biology at Shanghai Institute of Physical Biology, and Yan Wei, a professor at East China Normal University, have worked together to build an efficient DNA walking robot driven by nucleic acid exoceps.
they found that by regulating the composition, density, and orientation of DNA molecules on the surface of gold nanoparticles, they were able to significantly alter the interaction between enzyme molecules and DNA.
, by regulating the spatial excret of DNA molecules on the nano interface, a molecular machine that can realize the spontaneous movement of DNA molecules on the surface of gold nanoparticles is designed.
mechanism of this molecular machine can also be used to develop signal amplification strategies to achieve high sensitivity detection of DNA hybridization processes.
this research provides new principles and strategies for the design of new intelligent medical devices and molecular computers.
results were published in Angew.Chem.Int.Ed.2017, 56,1855.
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