An important enzyme is the key to fighting cancer and viral infections

A new study led by researchers at the University of California, Irvine (UCI) identified two ways to control APOBEC3A

APOBEC3A enzyme is an important part of the innate immune system.

"In our previous research, we proved that DNA mutations induced by apobec3a are very common in cancer patients

The study titled "Genotoxic stress and viral infection induce the transient expression of APOBEC3A and pro-inflammatory genes through two different pathways" was published today in the journal Nature Communications

In this study, Sunwoo Oh, a graduate student at UCI School of Medicine, and Dr.

Buisson said: "In short, our results reveal the different ways in which cells regulate APOBEC3A expression in response to different types of stress that cells may encounter

More work is needed to develop strategies to prevent the formation of cancer genomic DNA mutations caused by APOBEC3A, which increase tumor heterogeneity, promote disease progression and resistance to treatment

DOI 10.

Genotoxic Stress and Viral Infection Induce Transient Expression of APOBEC3A and Pro-Inflammatory Genes Through Two Distinct Pathways