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An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides

 Last Update: 2021-01-04
 Source: Internet
 Author: User

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The value of oligonucleotides as therapeutic agents has become increasingly apparent over the past decade (1 –3 ). In order to be useful as therapeutic agents, oligonucleotides must possess a number of properties. These include:

1.	Resistance to enzyme degradation;
2.	The ability to enter target cells;
3.	A lack of interference with normal DNA and RNA processing enzymes; and
4.	The ability to bind to a target and alter its expression in a sequence-specific manner.

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