An innovative NRF2 nanomodulator induces iron death of lung cancer and induces immune-stimulated tumor microenvironment

A nano- drug targeting both the tumor microenvironment and cancer cells has not been reported so far

Nano Tumor Nano (ZVI-NP) Tumor is a dual-functional nanomedicine that establishes an effective strategy for synergistically inducing iron chain cancer cell death and reprogramming the immunosuppressive microenvironment, which highlights ZVI-NP as an advanced comprehensive anti-cancer strategy Potential

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Zero-valent iron nanoparticles (Zvi) are widely used in the treatment of groundwater or wastewater containing a variety of organic and inorganic pollutants due to their strong reduction ability and wide availability

(Zvi) ZVI-NP Fenton (ROS) Tumor (TME) ZVI-NP(ZVI@Ag) ZVI-NP ROS ZVI-NP(ZVI@CMC) ZVI-NP ZVI-NP Tumor

Iron death is a new type of programmed cell death discovered in recent years

Iron death is a new type of programmed cell death discovered in recent years

Cancer immunotherapy, by enhancing the patient's own immune system to eliminate cancer cells, has completely changed the pattern of cancer treatment in the past decade

Cancer immunotherapy, by enhancing the patient's own immune system to eliminate cancer cells, has completely changed the pattern of cancer treatment in the past decade

ZVI-NPs

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In conclusion, this study determined the dual anti-cancer mechanism of ZVI-NP on non-malignant cells

This study determined the dual anti-cancer mechanism of ZVI-NP on non-malignant cells

Chih-Hsiung Hsieh et al.
An innovative NRF2nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatorytumor microenvironment.
Theranostics.
2021; 11(14): 7072-7091.
doi:10.
7150/thno.
57803

Chih-Hsiung Hsieh et al.
An innovative NRF2nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatorytumor microenvironment.
Theranostics.
2021; 11(14): 7072-7091.
doi:10.
7150/thno.
57803

Chih-Hsiung Hsieh et al.
An innovative NRF2nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatorytumor microenvironment.
Theranostics.
2021; 11(14): 7072-7091.
doi:10.
7150/thno.
57803