Analysis and detection of the quality index of the strength and barrier property of the false welding of the multi cavity infusion soft bag product

  At present, the multi cavity infusion soft bag is mainly divided into two kinds in the field of large infusion, one is the liquid-liquid multi cavity bag, the other is the powder liquid multi cavity bag It means that different infusion drugs are packed in the same package in the production process, storage and transportation process, separated in different chambers through virtual welding In clinical use, the virtual welding is opened through external force, and used after mixing The multi cavity soft liquid bag is soft Bag products are mainly suitable for unstable after preparation and cannot be preserved for a long time In clinical use, it is necessary to temporarily prepare infusion preparations In this paper, we only analyze two key quality factors of the soft bag product of multi cavity infusion, which are the false welding performance and the barrier performance 1 The analysis and detection of the strength of virtual welding for liquid-liquid multi cavity bag and powder liquid multi cavity bag, the strength of virtual welding must ensure that the convenience and safety of the clinical use of the product and the separation efficiency of the product in storage and transportation are not damaged, so the virtual sealing process control of the multi cavity bag product is a key step in the whole production process The performance of virtual welding mainly depends on the temperature, time and pressure On the one hand, in order to ensure the safety of storage and transportation, on the other hand, to ensure the ease of clinical use, the strength of the false welding (or called the thermal strength) cannot be too large or too small How to control this index has become the focus of multi cavity infusion bag manufacturers The hst-h3 heat sealing tester of Labthink blue light and the XLW (PC) intelligent electronic tensile tester are used for the detection of this index of multi cavity infusion software When testing the finished multicavity bag, the sample is directly cut from the part of false welding, and then the test can be completed automatically after selecting the test item of "heat sealing strength" on XLW (PC) In addition, as an infusion product manufacturer, in order to pursue the appropriate strength of the faulty welding, it is often necessary to study the temperature, time and pressure parameters of the welding seal At this time, it is necessary to analyze the temperature, time and pressure parameters of Zui with the help of hst-h3 heat seal tester and intelligent electronic tensile tester 2 Analysis and test of barrier performance Barrier performance is an important factor affecting the quality of multi cavity bag products No matter the liquid liquid multi cavity bag or powder liquid multi cavity bag, due to the low barrier of contact packaging of such products, in order to ensure that the products can block the penetration of oxygen and water vapor, it is necessary to add a layer of barrier packaging to the inner packaging (contact packaging) to block the penetration of oxygen and water vapor In addition, in the production process, the nitrogen replacement packaging machine is needed to replace the air between the inner bag and the barrier bag, so in the barrier test, in addition to testing the oxygen transmission, the nitrogen transmission, water vapor transmission and other indicators are also tested Labthink blue light's vac-v series of four differential pressure gas osmometers can well complete the detection of corresponding indicators The application of multi cavity bag is a significant improvement in the function of infusion soft bag As one of the strict packaging requirements of Zui in drug packaging, its testing indexes such as tensile strength and elongation, thermal strength, film puncture performance, rubber plug puncture force, sealing and other quality indexes also need to be tested As a testing instrument and testing service provider, Labthink Languang has continuously provided Zui and Zui comprehensive quality control solutions for the global pharmaceutical field for many years I hope to have more extensive exchanges and cooperation with enterprises and institutions in the pharmaceutical industry For details, please call: Guo Sijia GZ@