Analysis of global high-quality medical device cluster (I)

Original by Wei Hongze Minnesota's pillar industry is medical devices, and there are thousands of medical device enterprises, with the headquarters of many international giants Minnesota is also known as "Silicon Valley for medical devices." With the world's largest medical device company, Medtronic In addition, Boston science, Zimmer Biomet, St Jude Medical and other companies also have branches here 1 Talent advantages The University of Minnesota is one of the leading research public universities in the United States, known as "public Ivy", and one of the most comprehensive institutions of higher learning in the United States It's hard to understand the industrial comprehensiveness - the university has 25 Nobel laureates, 38 professors are academicians of the American Academy of Sciences, 35 professors are academicians of the National Academy of engineering, 16 professors are academicians of the National Academy of medicine and 57 professors are academicians of the American Academy of Arts and Sciences 2 solid industrial foundation Minnesota's computer industry research started and developed faster than Boston in the East and Silicon Valley in the West Since the end of World War II, a large number of computer engineers and scientists have gathered here, making Mingzhou quickly become the center of the computer industry in the United States Until now, Mingzhou university has cultivated a large number of computer experts every year Many of the world's top computer talents do not go to Silicon Valley, but stay there Local high-tech companies gather, including but not limited to: Alliance technology systems, ceridian, Cray, digi international, digital river, geek squad, Hutchinson technology, imation, IBM Rochester, Lawson software, macsoft, Medtronic, MTS systems, St Jude Medical, STRATASYS, SPS commerce, etc 3 R & D advantages The University of Minnesota has set up the Earl E Bakken Medical Devices Center to support innovation projects The R & D center's projects are closely linked with the University's scientific research, and the University's abundant scientific research funds also continuously provide new ideas for the R & D center of medical devices In addition, there is the world-famous Mayo Clinic (the first hospital in the United States); the University of Minnesota and Mayo Medical Center have long-term medical exchanges and cooperation The combination of companies, universities and top hospitals provides a perfect environment for the innovation of medical devices, which is also the basis for the emergence of innovative devices Massachusetts is the world's leading biotechnology super cluster, with six Biotechnology Clusters, more than 550 biotechnology and pharmaceutical companies, and more than 300 drug development companies As the core of Massachusetts, Boston area is the most dynamic biological industry cluster in the world, covering new drug research and development and production, medical and health products, medical devices and equipment, as well as environmental and veterinary fields According to data from the U.S Department of Commerce, Massachusetts ranks among the top five medical devices in terms of transportation value, employment, wages and added value, both in terms of per capita and absolute size Why is Massachusetts so successful in medical devices? The answer is simply that there are many hospitals in the region that attract a disproportionate share of federal R & D funding, which in turn facilitates technology transfer, business spin off, and opportunities for medical devices Company But what is the exact link between the medical device cluster and research intensive medical centers, such as the Massachusetts General Hospital in Massachusetts and the Mayo Clinic in Minnesota? What makes these regions different from many regions that have successful research intensive hospitals but lack a large number of counterparts in the medical device industry? Part of the answer lies in the long history of precision engineering and instrument manufacturing in Massachusetts, which has gone through many design iterations, from defense technology to microcomputers to information and communication technology to the life science industry today 1 Obvious advantages of basic science The long history of precision engineering and instrument manufacturing in Massachusetts is based on basic technology and industrial skills From national defense technology to microcomputers, information and communication technology, to the current life science industry, the whole development of Massachusetts is in the forefront of the United States, known as the "Eastern Silicon Valley" of the United States Massachusetts is one of the most important telecom equipment manufacturing states in the United States, and also the most intensive state of telecom equipment companies in the United States Famous enterprises include Bose Bosch, Millennium medicine, Fidelity Investment, Bank of America, new Bailun, Tera, staples, Raytheon, Gillette, etc 2 Strong innovation ability provided by top scientific research and human resources In Boston, Massachusetts, there are world-class university resources such as Massachusetts Institute of technology and Harvard University, as well as high-quality clinical medical resources such as Massachusetts General Hospital and New England Medical Center, as well as many advantageous discipline groups and laboratories leading the world in research fields such as life science, molecular biology, new materials and chemistry These three foundations actively interact with global pharmaceutical giants and start-ups to form the research and development mode "bed bench bed", namely "clinical laboratory clinical", or "BBB", which leads the latest development trend in the pharmaceutical field 3 Diversified support such as government finance and policy support has strengthened the ability to transform achievements In terms of industrial support, the local government launched the Massachusetts life science program in 2008, with the goal of investing $1 billion in life science research in the next decade Policy support includes financial support for scientific research achievements and provision of various tax incentives, financing channels and subsidies, such as "employment creation incentive project", "R & D tax relief policy", "Massachusetts emerging technology fund", etc In addition, the government also gathers innovative talents and strengthens the ability of achievement transformation by improving living environment, social welfare and providing industrial talents practice platform 4 Scientific research institutions play the function of business incubation Scientific research institutions also play a certain role in business incubation For example, the business incubation center of MIT has trained a batch of scientists and MIT's "50000 dollar entrepreneurship and competition" entrepreneurial fund for biotechnology enterprises to support entrepreneurs among students every year In the first five years of its establishment, it has supported the establishment of more than 35 companies 5 Obvious siphonage between large enterprises and small and medium-sized enterprises For small companies, it is more carried out through a "patent" or "idea", so the operation and R & D is more lightweight, and small enterprises are more willing to establish studios and laboratories around large enterprises, because they will get more advantages in software and hardware convenience, and most importantly, they will get more opportunities to communicate and cooperate with advanced enterprises For giants, they also rely more on small and medium-sized innovation companies to enrich and adjust their R & D pipeline (for example, acquisition is a more effective growth tool than innovation at a specific time) 1 Innovative new technology Innovative innovative device is a medical device with breakthrough innovation in function The proportion of such innovative devices is often relatively small There are very high requirements for the design and manufacture of products, and it is also a challenge for the FDA's approval personnel Because FDA has not been exposed to similar devices before, their approval process actually becomes a learning and research process of FDA itself For enterprises, the result is stricter requirements and longer approval time 2 Improved new technology When FDA evaluates new devices, it only requires that the efficiency of the device is greater than the risk This provides conditions for continuous innovation of medical devices This kind of innovation includes the re innovation of the performance and materials of the medical devices already on the market, so as to improve the performance of the medical devices and improve the use effect of doctors and patients; at the same time, it also includes the re innovation of the cost of the medical devices, so as to save costs for hospitals and patients and promote better products 3 Innovation of laws and policies American medical device regulations and policies have always been in the forefront of the world Trump signed the spending bill on December 20, which includes the permanent repeal of the 2.3% consumption tax on medical devices The abolition of consumption tax is a huge victory for the medical equipment industry According to a report released by Fortune magazine, the global medical equipment market scale in 2018 is US $425.5 billion, which is expected to reach US $612.7 billion by 2025 Data from the U.S Department of Commerce shows that the medical device industry has directly created more than 300000 jobs in the United States The U.S tax Foundation estimates that if the tax returns to force, it will reduce 21390 full-time jobs and reduce GDP by $1.7 billion 1 Diversified companies, diversified technology implementation and diversified medical applications By the end of the 1990s, Israel had more than 200 life sciences companies Over the past decade, Israel has maintained steady growth (about 40 new companies are established each year), and Israel has introduced creativity and innovation into the field of medical devices Today there are more than 1500 active companies In a relatively short period of time, 40% of these companies have started to make profits Israel's entrepreneurial ecosystem creates opportunities for start-ups to grow into advanced, commercially viable, and potential businesses As proof of industry development, the turnover of medical equipment and digital health care business in 2018 has exceeded US $2 billion, and has been growing steadily since 2010 Seed companies have rich channels and growth is expected to continue 2 The largest part of medical field is medical equipment and digital medical In the field of medical equipment, Israeli scientists and engineers have integrated advanced technologies in electronics, communication and Optoelectronics to develop world-class innovations in digital imaging, medical lasers, telemedicine, early diagnosis, intelligent surgical equipment, etc More than 600 medical device exporters are engaged in various medical applications, such as cardiovascular and peripheral blood vessels, neuropathy and degenerative diseases, preparedness and emergency medicine, intensive care, women's health care, orthopedics and sports medicine, gastrointestinal tract, infection control, ophthalmology, pain and wound management, oral and dental health care, dermatology and aesthetics 3 Outstanding innovation capability, known as the "power plant" of global medical device innovation In the past 20 years, American medical journals have selected 10 of the world's greatest new products (Inventions) in the field of medicine, among which three belong to Israel, namely, the swallowable capsule type digestive tract endoscope (PillCam), fingertip sleep and heart rate monitor (finger monitor) and emergency bandage (emergency bandage) 1 Talent advantages Israel has a number of world-class scientific research institutions, all of which are research and development bases and "incubators" for innovative products in Israel In the field of medicine, Hadassah Hospital in Jerusalem, Rambam hospital in Haifa City, ichilov hospital in Tel Aviv, chaimsheba medical center, Tel Aviv University, Weitzman University of science and technology, Hebrew University, etc are all famous in the world 2 Policy support The Israeli government has long recognized that it must take responsibility for business innovation The government of Israel has set up the office of chief scientist, and in 2015 approved the establishment of the National Bureau of technology and innovation (nati) as the chief scientist's office