Analysis of pulmonary Legionella balance, my scientists find new clues to conquer the "air-conditioned lungs"

Recently, a study by Professor Ouyang Songying of the School of Life Sciences of Fujian Normal University in cooperation with the Luo Zhaoqing Task Force of Purdue University in the United States provides a clue to the process of legionella infectionThe results are published in the internationally renowned journal European Society of Molecular Biology"Legion bacteria is not ordinary 'bandits', they are not only good at using offensive weapons 'to attack the city', but also know how to effectively and rationally recover and restore resources to ensure the long-term sustainable development of LegionellaOur study shows how Legionella affects germ reproduction through 'MvcA-MavC', a pair of 'mutual restraint weapons', using its unique balancing mechanism during infection, without allowing the immune system to harm the bacteria themselves and not continue to suppress the immune responseOuyang song should saybacteria "attack" also need to master a "degree"in daily life, we have to face a variety of pathogenic microorganisms, Legionella is one of themit is understood that more than 30 species of Legionella bacteria have been isolated, at least 19 species of human pneumonia pathogens, the most common of which is legionella, accounting for 85%-90%The bacteria was first discovered in Nanjing in 1982, and has since been found in Beijing, Shanghai and other citieslong and complex struggle between pathogenic microorganisms and humans, which increase their toxicity or pathogenicity through continuous reproduction, variation, and evolution"Ubiquitinmodification can regulate almost all processes in eukaryotic cells, especially in cell division and immune responseOuyang song should introduce that many pathogens in the long-term game with the host cell, evolved a variety of ways to interfere with the host's ubiquity modification system, so as to enhance the infestation efficiency and escape the host immune "monitoring" purposes"pneumoconiosis is mainly through an IV secretion system called Dot/Icm, which secretes about 330 effectproteins 'weapons' into the host cells, 'holding' and 'disturbing' the host's various signaling pathways, inhibiting the body's immune system to aid bacteria proliferation within the host cellOuyang song should sayOuyang song should point out that it is important to note that legionella can successfully infect the host, need to master a "degree": these "weapons" need to be able to hijack and suppress the host's immune system to complete the infection, at the same time can not be caused by excessive inhibition of the body's immunity decline and cause cell death, loss of survival of the "home."this "weapon" is the secret to the bacteria to maintain balance
in the host's immune response and cell survival process, there is an important "role" that can not be ignored - UBE2N Luo Zhaoqing found in the previous study that the effect protein MavC of legionella-addicted bacteria connected uprosdosin (Ub) to UNE2N to form UBE2N-Ub by some catalytic means, thus completing the ubiquitin modification of UBE2N and inhibiting its function Continuous suppression of the function of UBE2N will reduce the body's immunity, resulting in the death of infected cells, is not conducive to the proliferation of Legionella in the cells what does legionella do to reverse this inhibition process? In the latest study, scientists have given the answer, according to a reporter for Science daily " We found in our study that the MvcA gene, located downstream of MavC, an effect protein for legionella-addicted bacteria, encodes mvcA, an enzyme that specifically de-modifies UBE2N-Ub Surprisingly, MvcA and MavC are highly similar in protein sequence and structure, and both have ubiquitin deamidase function Ouyang song should say ", if you liken pneumoconiosis to a 'bandit' leader, the discovery is like 'bandit' leader sent 'two thieves' MavC and MvcA to work together Before the theft, MavC is responsible for masking UBE2N, making it easier to control the host After 5 hours, MvcA is responsible for releasing the host and then restoring the uBE2N function Professor Ouyang Song should be metaphorical thus show edgyp Legionella to meet the need to balance the uBE2N function of infected cells at different time periods by controlling mavC and MvcA expression during infection it is learned that Ouyang Song should be the task force on the lung legionella another major study, not only revealed the new function of MvcA and its catalytic mechanism, but also explore the two protein structure is highly similar but biochemical functions are very different reasons to provide clues, but also for the development of "air-conditioned lung" drugs to provide a new direction.