Analysis: Several main methods of chinese medicine compounding

there are many methods ofprescription, but the seven-feeling matching is the basic form of Chinese medicine matching, and Junchenzo is the main rule ofthe prescriptionThe purpose of the study of compounding is to remove invalid substances, optimize combination prescriptions, increase efficiency,detoxification, expand treatment scope, adapt to complex conditions, and prevent drug poisoningThere are mainly the following methods:literaturetheoretical research methods
from the classic examples of chinese medicine compound ingenuity, can enhance the efficacy of the drug; At present, we have begun to turn to the application of main factor analysis, cluster analysis and other statistical methods to the side evidence connotation or prescription characteristics to study, the use of computer technology for the ancient and modern prescription sedatives logic treatment, in order to more objective,more in-depth understanding of the prescription structure, from theof Chinese medicineevidence prescription medicine internally revealed prescription and application of the lawThe clinically validated research method, through clinical medical practice, investigates the relationship between the change of drug composition, thedrug dose change and theandefficacy of the main drugReliable efficacy of the prescription, not only targeted, just in the disease, but also must be cubic strict, the main sub-clear, in order to do this must be good at clever matchingSuch as Huang Lian with wood incense good treatment of hot blood after the emergency weight, with Wu Juyu long in the treatment of liver fire abdominal pain swallowing acid, with cinnamon is the treatment of heart and kidney insomniaThe dose is the basis of drug sex, and it is also an important factor to determine theof drug efficacy andchange of drug effect after the drug is decidedTake when the blood soup as an example,literaturerecorded when: the ratio of jaundice in addition to 1:5, there are 1:6(
the "Surgical Law"), 1:4
(
"Medical Understanding", "Time Song" , 1:3 (
1:3 the "Medical Department" , 1:2 (
") , 2:5 (
" Dong medical treasure) , 3:8 (The Introduction to Medicine) , 3:10 ("Women's Medicine") Clinical observation shows that when returned: jaundice is 1:
2 , the anti-hypoxia effect is the most significant; It can be seen that the different dose ratio son each has its own role advantages experimental research methods investigate the relationship between compounding, ratio and changes in chemical composition and pharmacological effects (1) Chemical research methods Study the changes in the amount and quality of chemical composition in the preparation of the preparation of the wood or cooking Such as lilicacid has anti-allergy, anti-inflammatory effect, which is closely related to the anti-cough effect of ephedrine soup Using HPLC to determine the content of licoric acid after frying and frying, the portion of the combined fried, licorice single frying Using HPLC to determine the effect of the different ratioofs between cinnamon and jaundice on the alkaloid content of jaundice, it was found that the greater the ratio of cinnamon, the less the content of jaundice alkaloids After chinese medicine is dispensed, there will also be ingredients that the original monotaste medicine does not contain Such as single-taste ginseng, wheat winter, five taste before cooking are free of 5-hydroxymethyl-
2 -glycoaldehyde (5-HMF), single-flavoured five-taste after frying to produce a small amount of 5-HMF, and when the raw veins are mixed with frying or five-taste, wheat winter with frying, produce a large number of 5-HMF, and 5-F has antioxidant and protective cardiovascular effect (2) Pharmacological research methods To study the relationship between different dispensing ratios and pharmacological effects, coordination effects and toxicity By observing the influence of different proportions of tantaum and white art (
2:1;1:1;1:1;1:1;1:1;1:1;1:
2
), Yu Shunqin and so on found that different ratios of the tweezers have different degrees of effect, with the ratio of stoicism to 1:
2 the most obvious This shows the rationality of the dose ratio relationship between the original group of the symbiotic pills, and proves that the change of the dose of Chinese medicine has a great influence on the effect of the compound ingerifying of Chinese medicine The drug pair is the most simple, basic and the most common form of Chinese medicine compounding, its matching is in line with the Chinese medicine the "seven feelings and combination" theory and combination principle, with the basic main treatment function and efficacy of the compound, can be revealed the law of the drug to the compound ingerifying scientific Liang Zhixin and others studied the effects of the combination of hemophilia soup and Kawakubo and Chizuno single-use on lipid reduction, antioxidant and blood vessel endothelial cell function in mice with high lipidemia, and the results showed that both drug combinations and single use significantly reduced serum cholesterol, triglycerides and LDL levels It is revealed that there is no synergy between the two drugs in terms of fat reduction However, the combination of the two drugs can reduce serum MDA levels and increase NO release This suggests that the two drugs have a synergistic effect in antioxidant and protective vascular endothelial cell function The matching can also play an efficiency-enhancing effect Such as the study of the law of four-reverse soup matching, although the appendage has a certain strong heart effect, but not strong, with strong heart effect is not strong dry ginger, can significantly enhance the contraction of the heart muscle, expansion of the coronary veins, which is consistent with the "phase" theory Moreover, the toxicity of the two-drug dispensary is greatly reduced Explain that the appendage is the main medicine of the party, it and the dry ginger matching wu that has the relationship between the courtiers, the dry ginger in the side can help the appendage to increase efficiency, and the production, including auxiliary and restrict the toxicity of the appendent (
/
Zhao Guoping, School of Medicine, Jinan University of
Medicine, Qian Sanqi, /
He Qinghu, University of Traditional Chinese Medicine, Hunan )