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Tumor necrotum (TNF) is an important inflammatory cytokine that plays a central role in autoimmune and inflammatory diseases.
in the pathogenesis of dry eye disease, inflammation is one of the main causes of dry stress and high osmosis pressure, resulting in cell damage and worsening inflammation of the eye surface, strengthening the vicious circle of dry eye disease.
press release, the Ternasip molecular weight is 19kDa, with good eye permeability, strong neutral activity of TNF-α, high stability, small side effects and so on.
it is through molecular engineering transformation to alleviate dry eye symptoms, specifically for the development of local ophthalmology drugs, its tissue distribution, stability and ability are optimized for the treatment of dry eye disease.
the upcoming project is a validation and comparability experiment in China.
results showed that Tenasip was effective quickly, showed significant improvement in signs measured by corneal staining scores (a measure of corneal damage), and had excellent tolerance and similar comfort to a placebo.
these results are consistent with those of Phase 2 clinical trials (VELOS-1) conducted in the United States with Platinum Pharmaceuticals partner HanAll.
safety and effectiveness results provide strong support for Ternasip's Phase 3 clinical registration trials in China.
is a chronic eye disease caused by many factors, which can cause visual impairment and long-term damage to the eye watch, seriously affecting the quality of life.
data show that 20%-30% of patients in China are currently affected.
and the incidence of dry eyes will continue to increase significantly as the global population ages, smartphone overuse and environmental changes.
: And Platinum Medicine will announce the results of the Clinical Phase II study of Tnasip (HBM9036) eye drops for patients with moderate to severe dry eye disease in China at the 25th National Ophthalmology Conference. Retrieved Nov 16, 2020, from Source: Medical Mission Hills
