Angew Hot Paper: flexible metal organic framework and acetylene induction fit through open metal sites, Li Dan team, Jinan University
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Last Update: 2019-05-22
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Source: Internet
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Author: User
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The molecular recognition of lead induced fit is the core of all biological processes, as well as the key to signal transmission, site activation and conformational change In solution state, supramolecular cages have been reported to have similar binding patterns (NAT Commun 2018, 9, 4530; J am Chem SOC 2014, 136, 4449) However, in rigid solid porous materials, it is very challenging to simulate the induced fit behavior of molecules Recently, Professor Lu Weigang and Professor Li Dan of the Institute of supramolecular coordination chemistry of Jinan University found the first flexible metal organic framework (jnu-1) which can be induced by acetylene through open metal sites Relevant research results were published in angew Chem Int ed (DOI: 10.1002/anie.201904160) and selected as hot paper by editors Prof Lu Weigang profile Prof Lu Weigang, doctoral supervisor, high-level university construction of Jinan University to introduce high-level talents In 1995, he graduated from the College of chemistry, Nanjing University with a bachelor's degree in polymer, and in 2002, he received a doctor's degree in organic chemistry from Zhongshan University and remained as a lecturer From 2005 to 2008, he worked in the Institute of biotechnology, Hong Kong University of science and technology in the research of anti Alzheimer's drugs In 2008, he went to the United States to carry out postdoctoral research in the group of Professor Zhou Hongcai of Texas A & M University, mainly engaged in structural design and directional synthesis of new porous frame materials and their application in gas adsorption and separation In 2016, he served as a research scientist at Fayetteville State University, during which he was approved to receive two grants from the National Natural Science Foundation of the United States (one for hosting and one for CO hosting) In July 2018, he joined the Institute of supramolecular coordination chemistry of Jinan University Now, he is mainly engaged in the research on the host and guest of flexible frame materials, exploring their application in the field of clean energy and biological detection In recent years, more than 40 papers have been published in J am Chem SOC., angel Chem Int ed., chem SOC rev, energy energy energy SCI, adv.mater And other international authoritative academic journals, and the papers have been cited more than 4000 times Prof Li Dan profile Prof Li Dan, doctoral supervisor, Dean of School of chemistry and materials, winner of National Science Fund for Distinguished Young Scholars (2008), has presided over key projects, major research projects, general projects of National Science Fund and national 973 Project leader, etc Professor Li Dan is committed to the research work on the synthesis and assembly, structural morphology, luminescence, adsorption and chirality of supramolecular complexes and their aggregates He has published more than 170 academic papers in international authoritative academic journals such as j.am.chem.soc., angel.chem.int.ed., chem Rev He cited more than 6000 SCI papers with an H-index of 54 Professor Li Dan is the "government special allowance expert" of the State Council, selected as the leader of the "one million talents project" of the national ten thousand talents plan, the fourth batch of advanced individuals of the training objects of the "one hundred and ten projects" of Guangdong Province; he has won the first prize of science and technology of Guangdong Province (the first adult), the "model worker" of Guangdong Province, and the famous teacher of Guangdong Province He was vice president of Shantou University and won the excellent teaching award of Li Ka Shing Foundation Now he is FRSC, Council member of China Chemical Society, vice president of Guangdong chemical society and executive director of Guangdong material society Introduction to Institute of supramolecular coordination chemistry of Jinan University In, Professor Li Dan, the winner of the national fund for Distinguished Young Scholars, served as the director, aiming to carry out research on molecular design, synthesis technology, crystal engineering and material creation of coordination supramolecular functional materials with great scientific significance and application prospect, with special attention to metal organic cage and metal- Limited space host guest chemistry of functional supramolecular systems such as organic framework and its exploration in energy, environment, biomedicine and other fields The research of the Institute is supported by key projects of NSFC, key supporting projects of major research programs, general projects and provincial and ministerial scientific research projects At present, there are 6 faculty members, including 4 professors, 1 national outstanding youth, 1 leading talent of "ten thousand talents plan", 1 National candidate of "one million talents project in the new century", and 1 outstanding youth of Guangdong Province Now there are more than 40 postdoctoral, doctoral and master students Frontier research results: the research on the induction fit of flexible metal organic framework (MOF) with acetylene through open metal sites shows that MOF )Through ligand functionalization, pore shape customization, surface polarization and incorporation of open metal sites, the force on specific gas molecules can be significantly enhanced, and then the selectivity of specific gas in the mixture can be improved However, most of MOF materials have rigid frames With the increase of gas adsorption, the frame size hardly changes Once the strong adsorption sites in the frame are occupied by specific gases, the affinity for gas molecules will inevitably decrease In order to solve this problem, researchers from Jinan University introduced the inductive fit effect of enzyme into MOF A flexible metal organic framework jnu-1 with one-dimensional diamond pore was synthesized from zinc nitrate and 5-carboxybenzotriazole The inductive fit with acetylene was realized by opening metal sites Through in-situ single crystal, powder diffraction and molecular simulation, the researchers found that as the adsorption of acetylene continued to contract, the force of jnu-1 on acetylene continued to increase This unique induction fit behavior endows jnu-1 with unprecedented acetylene affinity, and the adsorption enthalpy reaches 47.6 kJ mol-1 The results of in-situ powder diffraction show that the framework shrinks continuously with the adsorption of acetylene, which is beneficial to enhance the interaction between the framework and acetylene Fig 1 in situ powder X-ray diffraction of jnu-1 (source: angelw Chem Int ed.) single crystal X-ray diffraction shows that site I of acetylene molecule is coordinated with two open metal sites Researchers can also clearly observe the interaction between acetylene molecules at site II and acetylene molecules at site 1 Fig 2 single crystal X-ray diffraction of C2H2 @ jnu-1 (source: angel Chem Int ed.) by calculating the adsorption enthalpy (QST), the researchers found that the adsorption enthalpy of jnu-1 for acetylene continued to increase with the adsorption of acetylene, and this abnormal phenomenon was not reported in the adsorption of gas molecules by MOF materials Through the experiments of acetylene / carbon dioxide penetration, it is found that the mixture of acetylene and carbon dioxide (volume ratio 50 / 50) passes through the activated jnu-1 solid packed column, and the signal of carbon dioxide appears in the penetration time of 75 minutes, while acetylene appears 150 minutes later, which proves that jnu-1 has a very good separation effect on the two Figure 3 summary of adsorption enthalpy and breakthrough curve of jnu-1 (source: angel Chem Int ed.): induced fit effect is an effective method to enhance the force between flexible metal organic framework and gas molecules, which provides a new design idea for gas mixture separation Review of previous reports: Professor Li Dan's research group of Jinan University: can achiral substances have optical activity? Today, people and scientific research are increasingly valued in the economic life of scientific and technological elements, China ushered in the "node of scientific and technological explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeangoapp, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.
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