Anhui Agricultural University research team found that drinking green tea may prevent and delay Alzheimer's disease

Original title: Anhui Agricultural University research team found that drinking green tea may prevent and delay Alzheimer’s

With the aging of the population, neurodegenerative diseases represented by Alzheimer disease (AD) are showing a rapid and high incidence trend

Recently, Anhui Agricultural University tea biological science and resource utilization state's key experiments room (Anhui laboratory) Professor Wan Xiaochun and China Cooperative Research University of Science and Technology Professor Shen Yong team found that green tea can prevent and delay 5XFAD transgenic mouse brain β starch Formation of Aβ -like protein , reduce nerve synapse damage and improve learning and memory ability

The study used green tea extract (GTE) to intervene in human-derived amyloid precursor protein (APP) and presenilin (PS1) double transgenic 5XFAD mice, and found that GTE was significantly reduced at the same dose of human daily tea consumption The content of Aβ in the brain of mice and reduces the expression of cleavage products of APP amyloid pathway (sAPPβ and C99) and non-amyloid pathway (sAPPα and C83); reduces the content of inflammatory factor IL-1β and glial cell markers in the brain The expression of Iba1 and GFAP inhibits its excessive activation; at the same time, GTE significantly increases the expression of neurosynaptic proteins PSD95 and Synaptophysin, and reduces the neurotoxicity caused by Aβ; behavioral tests such as Barnes maze and Y maze further prove that GTE intervention significantly improves 5XFAD Mouse cognitive ability

PhD candidates Kan Zhipeng and Associate Professor Wang Yijun of the State Key Laboratory of Tea Tree Biology and Resource Utilization are the co-first authors of the paper, and Professor Wan Xiaochun and Associate Researcher Gao Feng of the University of Science and Technology of China are the corresponding authors of the paper

(This article is reprinted by "Food Science Network", and the article is from Anhui Agricultural University