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    Home > Food News > Food Articles > Animal experiments have shown that the adverse effects of a high-fat diet can be passed down from generation to generation

    Animal experiments have shown that the adverse effects of a high-fat diet can be passed down from generation to generation

    • Last Update: 2021-03-14
    • Source: Internet
    • Author: User
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    high-fat diet in female mice can affect obesity, insulin resistance and addictive behavior in three generations, according to a new study.
    Researchers from the Federal Institute of Technology in Zurich, Switzerland, found that mice on a high-fat diet before, during and after pregnancy exhibited addictive behaviors such as increased drug sensitivity and preference for drugs, as well as changes in obesity-related characteristics, such as metabolism. In the third generation, or great-grandchildren, the researchers observed some gender differences, with only females having addictive behavior and only males having obesity characteristics. Although the first female mice were not obese themselves, and the 1st generations of mice did not take a high-fat diet, this is still the case.
    So far, most studies have only observed the long-term effects of obesity and diabetes in second-generation generations, or only in the first generation," said study co-author Daria Peleg-Raibstein. The study is the first to look at the effects of overealing on addiction and obesity in mothers up to a third generation. In a recent report published in the open-access journal Translational Psychiatry, the researchers analyzed these effects, especially through male offspring, until a third generation.
    their practice is to feed female mice high-fat or a normal diet for 9 weeks before mating, during pregnancy and lactation, respectively. The male offspring of these mice then mate with standard-fed female mice, ingesting a second generation. Male offspring of the second generation once again mate with female mice in the standard diet, ingesting third-generation offspring. The researchers measured the weight, insulin sensitivity, metabolic rate, and associated blood indicators, such as insulin and cholesterol levels, of second- and third-generation offspring. In behavioral experiments, they looked at whether mice were more likely to opt for a high-fat diet than a standard laboratory diet, or preferred an alcohol solution over water, and how active the mice were after using amphetamines. They did so to better understand whether the high-fat diets of matrists affected obesity, overealing and drug sensitivity in future generations.
    to combat the current obesity epidemic, it's important to understand the mechanisms behind it and find ways to prevent it early," said Peleg-Raibstein, a professor at the U.S. Centers for Disease Control and Prevention. New research could help improve health counseling and education for pregnant and lactating couples, making it more likely that their children, grandchildren and great-grandchildren will live in a healthy lifestyle. It provides a possible way to help people find high-risk factors for obesity and addiction, and provides advice for early intervention in high-risk groups. "
    " wants to draw conclusions from mice to people, there is still a long way to go. Peleg-Raibstein added, "But it's almost impossible to study the effects of overealing on mothers in humans because there are too many distractions, such as socioeconomic backgrounds, parents' food preferences, or their current health." Mouse models allow us to study the effects of a high-fat diet on future generations without these factors interfering. Further
    further research is needed to determine the molecular structure of the effects of a woman's high-fat diet passed on to future generations, the researchers said. (Source: Feng Weiwei, China Science Journal)
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