Ann Clin Transl Neurol: CXCR4 aortics stimulate the regeneration of axons after sebra nerve damage.

The purpose of this study is to test whether the signal axis CXCL12 alpha-CXCR4 is activated after the setan nerve is squeezed/cut, and to test the activity of the new CXCR4 astration nuCC-390 in promoting nerve damage recovery, the results of which were published online in Ann Clin Transl Neurol.
crush or cut off the sebra nerve.
the expression and positioning of CXCL12 alpha and CXCR4 through specific antibody imaging.
their function in neuroregeneration is determined by neutralizer CXCL12 alpha, and CXCR4 specific antagonist AMD3100, using a composite muscle action head (CMAP) as a quantitative reading.
the activity of NUCC-390 to neurogeneration through imaging and CMAP records.
results showed that CXCR4 was expressed at the damaged site within the axon, while its lid, CXCL12 alpha, was expressed in Schwan cells.
CXCL12 alpha-CXCR4 axis is involved in the recovery of nerve transmission in injured nerves.
, the small molecule NUCC-390 strongly promotes nerve function and anatomical recovery by acting very similarly to CXCL12 alpha.
this pharmacological effect is due to nuCC-390 in vitro and in vivo can promote the elongation of motor neuron axons.
, imaging and electrophysiological data provide new and compelling evidence that the CXCL12 alpha-CXCR4 axis is involved in seth nerve repair after crushing/cutting.
makes NUCC-390 a strong candidate molecule that stimulates nerve repair by promoting axon elongation.
the molecule in other neuron damage models to lay the foundation for clinical trials of NUCC-390 in the repair of nerves around the human body.
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