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Ann Intern Med: Influence of frailty on the efficacy and safety of dapagliflozin in heart failure patients with reduced ejection fraction

 Last Update: 2022-05-13
 Source: Internet
 Author: User

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Frailty may alter the risk-benefit profile of some treatments, and frail patients may have reduced tolerance to treatment

prevention

The study is a post hoc analysis of a phase 3 randomized clinical trial conducted at 410 sites in 20 countries (ClinicalTrials.

Guidelines for Heart Failure Vascular

Frailty index (FI) was calculated in 4742 of the 4744 randomly assigned DAPA-HF patients

CONCLUSIONS: Dapagliflozin improved outcomes across all assessments, regardless of the patient's frail status

Original source:

Jawad H.

Jawad H.
Butt, et al.
Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction A Post Hoc Analysis of the DAPA-HF Trial .
Ann Intern Med 2022.
https:// /10.
7326/M21-4776 Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction A Post Hoc Analysis of the DAPA-HF

Trial

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