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Ann Intern Med: Safety and immunological efficacy of live varicella-zoster vaccine in patients receiving tumor necrosis factor inhibitors

 Last Update: 2022-01-22
 Source: Internet
 Author: User

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The safety and efficacy of live viral vaccines, such as the varicella-zoster vaccine, in patients with inflammatory diseases receiving immunomodulatory
therapy, such as tumor necrosis factor inhibitors (TNFis), are unknown .

A study published in Ann Intern Med evaluated the safety and immunogenicity of live attenuated varicella vaccine (ZVL) in patients treated with TNFis

immunity

Using a randomized, blinded, placebo-controlled design, adults 50 years of age and older receiving TNFis were randomized to ZVL versus placebo
.

Glycoproteinase-linked immunosorbent assay (gpELISA) and enzyme-linked immunosorbent assay (ELISpot) of serum and peripheral blood mononuclear cells were measured at baseline and 6 weeks after vaccination

Infect

RESULTS: From March 2015 to December 2018, a total of 617 participants were included in the study, randomized 1:1 to receive ZVL (n = 310) or placebo (n = 307) at 33 centers
.

Mean age was 62.

rheumatoid arthritis

Taken together, the findings provide evidence for the safety of live virus vaccines in patients receiving biologics
.

A limitation of the study is that generalizability to patients receiving other types of immunomodulators may be limited

Original source:

Jeffrey R Curtis, et al.

The Safety and Immunologic Effectiveness of the Live Varicella-Zoster Vaccine in Patients Receiving Tumor Necrosis Factor Inhibitor Therapy : A Randomized Controlled Trial

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