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    Home > Active Ingredient News > Antitumor Therapy > Ann Oncol: Second-line Osimertinib (osimertinib) combined with bevacizumab does not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC

    Ann Oncol: Second-line Osimertinib (osimertinib) combined with bevacizumab does not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC

    • Last Update: 2022-03-04
    • Source: Internet
    • Author: User
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    Osimertinib (Osimertinib) is the standard second-line treatment for patients with EGFR-mutant NSCLC who acquire the T790M mutation, and the efficacy of its combination with bevacizumab is unclear
    .


    Therefore, the results of a phase II study, BOOSTER, were published in Annals of Oncology, evaluating second-line Osimertinib (osimertinib) combined with bevacizumab versus Osimertinib (osimertinib) monotherapy in patients with EGFR T790M-mutated advanced NSCLC.


    Osimertinib (Osimertinib) is the standard second-line treatment for patients with EGFR-mutant NSCLC who acquire the T790M mutation, and the efficacy of its combination with bevacizumab is unclear


    The BOOSTER study is an open-label, randomized Phase II clinical study
    .


    The primary study endpoint was investigator-assessed progression-free survival (PFS)


    The BOOSTER study is an open-label, randomized Phase II clinical study


    Between May 2017 and February 2019, 155 patients were randomized (combination arm: 78; single-agent arm: 77)


    The median follow-up time was 33.


    PFS

    PFS

    In subgroup analysis, the combination group improved median PFS in current and former smokers [HR: 0.
    57 (0.
    33-0.
    98); Wald's test P=0.
    043], but not in non-smokers (HR: 1.
    29 ( 0.
    82-2.
    02); Wald's test P=0.
    28)
    .

    In subgroup analysis, the combination group improved median PFS in current and former smokers [HR: 0.
    57 (0.
    33-0.
    98); Wald's test P=0.
    043], but not in non-smokers (HR: 1.
    29 ( 0.
    82-2.
    02); Wald's test P=0.
    28)
    .


    In subgroup analysis, the combination group improved median PFS in current and former smokers [HR: 0.


                 Differences in PFS treated with different smoking status

    Differences in PFS treated with different smoking status

    Median OS was 24.
    0 months (95% CI 17.
    8-32.
    1) in the combination arm versus 24.
    3 months (95% CI 16.
    9-37.
    0) in the monotherapy arm, with no significant difference in OS [log-rank P =0.
    89; HR: 1.
    03 (0.
    68-1.
    56)
    .


    The combination group numerically prolonged median OS in current and former smokers [HR: 0.


    Median OS was 24.


                  OS

    OS

                Differences in OS between different smoking statuses

                Differences in OS between different smoking statuses

    ORR was 55% (95% CI 43%-66%) in both treatment arms and DCR was 90% (95% CI 81%-95%) and 82% (95%) in the combination arm and monotherapy arm, respectively CI 71%-90%) (P=0.
    17)
    .

    ORR was 55% (95% CI 43%-66%) in both treatment arms and DCR was 90% (95% CI 81%-95%) and 82% (95%) in the combination arm and monotherapy arm, respectively CI 71%-90%) (P=0.
    17)
    .


    ORR was 55% (95% CI 43%-66%) in both treatment arms and DCR was 90% (95% CI 81%-95%) and 82% (95%) in the combination arm and monotherapy arm, respectively CI 71%-90%) (P=0.


    In the safety cohort, 152 of 153 patients (99%) experienced at least one AE of any grade (76 in each group)


    In conclusion, the study showed that Osimertinib (osimertinib) combined with bevacizumab second-line therapy did not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC
    .

    In conclusion, the study showed that Osimertinib (osimertinib) combined with bevacizumab second-line therapy did not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC
    .
    Studies have shown that Osimertinib (osimertinib) combined with bevacizumab second-line therapy does not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC
    .
    Studies have shown that Osimertinib (osimertinib) combined with bevacizumab second-line therapy does not significantly improve the prognosis of patients with T790M mutation in EGFR-mutant advanced NSCLC
    .

    Original source:

    Original source:

    Soo RA, Han JY, Dafni U, et al.
    A randomised phase II study of osimertinib and bevacizumab versus osimertinib alone as second-line targeted treatment in advanced NSCLC with confirmed EGFR and acquired T790M mutations: the European Thoracic Oncology Platform (ETOP 10- 16) BOOSTER trial.
    Ann Oncol.
    2022 Feb;33(2):181-192.
    doi: 10.
    1016/j.
    annonc.
    2021.
    11.
    010.
    Epub 2021 Nov 26.
    PMID: 34839016.

    Soo RA, Han JY, Dafni U, et al.
    A randomised phase II study of osimertinib and bevacizumab versus osimertinib alone as second-line targeted treatment in advanced NSCLC with confirmed EGFR and acquired T790M mutations: the European Thoracic Oncology Platform (ETOP 10- 16) BOOSTER trial.
    Ann Oncol.
    2022 Feb;33(2):181-192.
    doi: 10.
    1016/j.
    annonc.
    2021.
    11.
    010.
    Epub 2021 Nov 26.
    PMID: 34839016.
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