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Idiopathic inflammatory myopathy (IIM) is a group of systemic autoimmune connective tissue diseases.
Based on its clinical and immunopathological characteristics, it is mainly divided into three subtypes: polymyositis, dermatomyositis and inclusion body myositis.
Among them, polymyositis and dermatomyositis are the most common
.
The clinical manifestation is non-suppurative inflammation of skeletal muscle mainly caused by weakness of the proximal extremities.
The extent to which genetics affects idiopathic inflammatory myopathy (IIM) is currently unclear
.
This research, published in Ann Rheum Dis, a top journal in the field of rheumatism, analyzed the family clustering and heredity of IIM
This is a family-based study using data from the Swedish National Health Care Registry
.
Match IIM patients with non-IIM patients, find their first-degree relatives and determine whether all first-degree relatives have IIM
The study included 1620 patients diagnosed with IIM from 1997 to 2016 and their 7615 first-degree relatives, 7797 non-IIM patients and 37309 first-degree relatives
.
Compared with non-IIM patients, first-degree relatives of IIM patients are more likely to have IIM (aOR=4.
Diagnosis compared with patients with non-IIM, IIM first-degree relatives of patients are more likely to suffer from IIM (aOR = 4.
Figure: 95% confidence interval of IIM estimation heritability (gray area)
Figure: 95% confidence interval of IIM estimation heritability (gray area)It can be seen that IIM has a family genetic component, and there is a risk of family aggregation in first-degree relatives, and its heritability is about 20%
.
This is important for future etiological research and clinical consultation
IIM has a family genetic component, there is a risk of family aggregation in first-degree relatives, and its heritability is about 20%
Original source:
Original source:Weng Ian Che.
Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies.
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