Ann Rheum Dis: Tumor necrosis factor inhibitors can slow the imaging progress of aggressive spina bifida.

Tumor necrosis factor inhibitors () have been shown to slow the imaging progress of aggressive spina bifidaHowever, the limitation factors such as changes in disease activity, complex drug management and short follow-up time make it difficult to determine the impact on imaging progressThe purpose of this study is to use years of vertical real-world data to explore whether long-term use can reduce imaging progress in patients with severe spina bifidaThis retrospective study was conducted in a single centre from year to yearThe electronic medical records of patients were reviewed and the patients who had been used at least once were includedThe interval between exposure or non-exposure of patients (use or non-use intervals, respectively) was determinedThe difference in the rate of change () in improved spinal scoliosis spinal score () was analyzed between use and non-use intervalA total of individual intervals were obtained for case patients ("Use" intervals for "do not use" intervals)The rate of change in marginal structural models of treatment weight inverse probability decreased significantly (beta) and adjusted changes in non-use intervals were annual and respectivelyUse significantly slows imaging progress compared to non-use therapy