Ann Surg: Liver transplantation provides a longer total lifetime for colorectal cancer patients with non-removable liver metastasis

The total five-year survival rate of non-removable colorectal cancer patients receiving palliative chemotherapy was about 10%.
previous study (SECA-I), liver transplantation provided patients with a 60 percent overall survival rate.
risk factors for death are cancerous embryo antigens (CEA), progression during chemotherapy, maximum lesions size of 5.5cm, less than 2 years from primary tumor removal to transplantation.
forward-looking (SECA-II) study aims to assess the total and disease-free survival of some non-excisible colorectal cancer patients who receive liver transplants, the results of which were published online in Ann Surg.
study included non-excisible liver-only colorectal cancer patients identified by computerized fault scanning (CT)/magnetic resonance imaging/positive electron emission lithography, and responded at least 10% to chemotherapy.
time from diagnosis to liver transplantation is more than 1 year.
, Kaplan-Meier had a total survival rate of 100 per cent, 83 per cent and 83 per cent, respectively, at 36 months of medium follow-up.
53%, 44% and 35% disease-free in 1, 2 and 3 years, respectively.
survival rates were 100%, 73% and 73%, respectively, when they relapsed in 1, 2 and 4 years.
is mainly a slow-growing lung metastasis tumor, which can be cured.
the diagnosis of Fong clinical risk score of 1 to 2 points, disease-free survival than 3 to 4 points longer (P -0.044).
the patient prognosis factors included in this study were significantly better than in previous SECA-I studies.
results show that liver transplantation provides the longest total lifetime for colorectal cancer patients with non-removable liver metastasis.
improved selection criteria make the five-year total survival of patients with non-removable colorectal cancer liver metastasis comparable to other liver transplantation adaptations.
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